XPO1 - exportin 1 Gene

Also Known as emb; CRM1; exp1; CRM-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7514

About XPO1

Cytogenetic location: 2p15 Genomic coordinates (GRCh38): 2:61,477,849-61,538,612 (from NCBI)

This gene has 55 transcripts (splice variants), 229 orthologues, 1 paralogue and is associated with 91 phenotypes. Ubiquitous expression in testis (RPKM 38.6), lymph node (RPKM 33.8) and 25 other tissues.

Summary

This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

XPO1 Products (2)

mRNA	Protein	Name
NM_001410799.1	NP_001397728.1	exportin-1 isoform 2
NM_003400.4	NP_003391.1	exportin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables nuclear export signal receptor activity	IDA IDA: Inferred from direct assay	29666234	GOA
enables nuclear export signal receptor activity	IMP IMP: Inferred from mutant phenotype	12724356	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10358091	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in nucleocytoplasmic transport	IMP IMP: Inferred from mutant phenotype	11000203	GOA
involved in protein export from nucleus	IDA IDA: Inferred from direct assay	22250199	GOA
acts upstream of or within protein export from nucleus	IMP IMP: Inferred from mutant phenotype	22427340	GOA
involved in protein export from nucleus	IMP IMP: Inferred from mutant phenotype	12773398	GOA
involved in protein export from nucleus	IPI IPI: Inferred from physical interaction	29666234	GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	29666234	GOA
involved in ribosomal large subunit export from nucleus	IMP IMP: Inferred from mutant phenotype	12773398	GOA
involved in ribosomal small subunit export from nucleus	IMP IMP: Inferred from mutant phenotype	12773398	GOA
involved in ribosomal subunit export from nucleus	IMP IMP: Inferred from mutant phenotype	12724356	GOA
involved in ribosome biogenesis	IMP IMP: Inferred from mutant phenotype	12724356	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in annulate lamellae	IDA IDA: Inferred from direct assay	12210765	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23782956	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	17363900	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	23782956	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	10557333	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	18809582	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XPO1 Protein Structure

IBN_N

Xpo1

CRM1_C

0
200
400
600
800
1000
1071 a.a.

Protein Preferred Names	Protein Names
exportin-1	chromosome region maintenance 1 homolog

XPO1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	XPO1	O14980	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	XPO1	O14980	DHX9	Homo sapiens	Q08211	Anti Bait CoIP	19955415
Intra	XPO1	O14980	PHB1	Homo sapiens	P35232	Anti Bait CoIP	16319068
Intra	XPO1	O14980	TP53	Homo sapiens	P04637	Anti Bait CoIP	17268548
Intra	XPO1	O14980	TP53	Homo sapiens	P04637	Anti Bait CoIP	18952844
Intra	XPO1	O14980	BIRC5	Homo sapiens	O15392	Pull Down	17099693
Intra	XPO1	O14980	SNUPN	Homo sapiens	O95149	ITC	19339969
Intra	XPO1	O14980	SNUPN	Homo sapiens	O95149	X-Ray Diffraction	19339969
Intra	XPO1	O14980	SNUPN	Homo sapiens	O95149	Pull Down	19339969
Intra	XPO1	O14980	SNUPN	Homo sapiens	O95149	SAXS	23850451
Intra	XPO1	O14980	SNUPN	Homo sapiens	O95149	GMS	19339969
Intra	XPO1	O14980	SNUPN	Homo sapiens	O95149	Pull Down	19339972
Intra	XPO1	O14980	RCC1	Homo sapiens	P18754	Anti Tag CoIP	35271311
Cross	XPO1	O14980	rev	Human immunodeficiency virus	P04618	Pull Down	19339969
Cross	XPO1	O14980	rev	Human immunodeficiency virus	P04618	Pull Down	19339972

Cross: Cross-species interaction Intra: Intraspecies interaction

XPO1 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81809	CRM1 Antibody (YA1554)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Primary Mediastinal Large B-Cell Lymphoma	Mediastinal Large B-Cell Lymphoma Large Cell Lymphoma Of The Mediastinum Med-Dlbcl Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type Mediastinal Large B-Cell Lymphoma
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Venezuelan Equine Encephalitis	Venezuelan Equine Fever Venezuelan Equine Encephalomyelitis Encephalitis Venezuelan Equine Encephalomyelitis, Venezuelan Equine Venezuelan Encephalitis Disorder Due To Venezuelan Equine Encephalitis Virus Venezuelan Equine Encephalitis Virus Infection Venezuelan Equine Encephalomyelitis Virus Disease
Suppression Of Tumorigenicity 12	Prostate Adenocarcinoma Adenocarcinoma Of Prostate ST12 Prostate Adenocarcinoma 1 Pac1
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Mediastinal Gray Zone Lymphoma	Mediastinal B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Mediastinal Malignant Lymphoma	Lymphoma Of Mediastinum Mediastinal Lymphoma
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Chromosome 2p16.1-P15 Deletion Syndrome	2p15p16.1 Microdeletion Syndrome 2p15-P16.1 Microdeletion Syndrome Del(2)(P15p16.1) Monosomy 2p15p16.1 Monosomy 2p15-P16.1
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Primary Mediastinal B-Cell Lymphoma	Large Cell Lymphoma Of The Mediastinum Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Peroxisome Biogenesis Disorder 11a	PBD11A Peroxisome Biogenesis Disorder Complementation Group 13 PBD-CG13 Cg13 Pbd-Cgh Peroxisome Biogenesis Disorder Complementation Group H Peroxisome Biogenesis Disorder, Type 11a Peroxisome Biogenesis Disorder, Complementation Group 13
Retinitis Pigmentosa 61	RP61 Retinitis Pigmentosa, Type 61
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-100423	Eltanexor	Inhibitor	99.84%	Phase 2
HY-15970	Verdinexor		99.94%	Phase 1

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-170669	PROTAC XPO1 degrader-1		99.77%	Unkown
HY-164710	Biotinylated leptomycin B		99.32%	Unkown
HY-144763	XPO1-IN-1	Inducer	98.08%	Unkown
HY-W010525	Piperidin-4-ylmethanamine		/	Unkown
HY-RS15889	XPO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-113902	(2-(β-Piperidinoethyl)-9-hydroxyellipticinium chloride	Inhibitor	/	Unkown
HY-161391	CW0134	Modulator	/	Unkown
HY-161392	CW2158	Modulator	/	Unkown
HY-170671	E3 ligase Ligand 49		/	Unkown
HY-170672	XPO1-ligand-1	Ligand	/	Unkown
HY-170673	E3 Ligase Ligand-linker Conjugate 156		/	Unkown
HY-174132	CW8001	Inhibitor	/	Unkown
HY-163902	SP100030 analogue 1	Inhibitor	/	Unkown
HY-RS16700	Xpo1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23134	Xpo1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	XPO1	RGD	RGD:620517
Felis catus	XPO1	VGNC	VGNC:81260
Mus musculus	XPO1	MGD	MGI:2144013
Bos taurus	XPO1	VGNC	VGNC:36997
Macaca mulatta	XPO1	VGNC	VGNC:78812
Canis familiaris	XPO1	VGNC	VGNC:48460
Others	XPO1	NCBI