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United States

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Cat. No.: HY-161389

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SP-alkyne

Name: SP-alkyne
Brand: MedChemExpress
SKU: HY-161389
Price: 997.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

SP-alkyne (compound 8) suppresses IL-2 production and AP-1 and NFAT reporters.

For research use only. We do not sell to patients.

Formula: C₁₅H₆ClF₆N₃O
Molecular Weight:393.67

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Data Sheet (267 KB)

SP-alkyne Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

SP-alkyne (compound 8) suppresses IL-2 production and AP-1 and NFAT reporters^[1].

All Interleukin Related Isoforms :

Chemical Information

Appearance Solid
Molecular Weight 393.67
Formula C₁₅H₆ClF₆N₃O
SMILES

C#CC1=CC(NC(C2=C(C(F)(F)F)N=C(Cl)N=C2)=O)=CC(C(F)(F)F)=C1
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yi Fan Chen, et al. Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation. Nat Chem Biol. 2024 Mar 25. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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SP-alkyne

All Interleukin Related Isoforms