CD70 - CD70 molecule Gene

Also Known as CD27L; LPFS3; CD27-L; CD27LG; TNFSF7; TNLG8A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 970

About CD70

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,581,648-6,591,150 (from NCBI)

This gene has 3 transcripts (splice variants), 88 orthologues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

CD70 Products (2)

mRNA	Protein	Name
NM_001252.5	NP_001243.1	CD70 antigen isoform 1
NM_001330332.2	NP_001317261.1	CD70 antigen isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12324477	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	8387892	GOA
enables receptor ligand activity	IMP IMP: Inferred from mutant phenotype	28011863	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in B cell mediated immunity	IMP IMP: Inferred from mutant phenotype	28011864	GOA
involved in B cell proliferation	IMP IMP: Inferred from mutant phenotype	28011864	GOA
involved in CD27 signaling pathway	IDA IDA: Inferred from direct assay	8387892	GOA
involved in T cell activation	IDA IDA: Inferred from direct assay	8387892	GOA
involved in T cell mediated immunity	IMP IMP: Inferred from mutant phenotype	28011864	GOA
involved in adaptive immune memory response involving T cells and B cells	IMP IMP: Inferred from mutant phenotype	28011863	GOA
involved in extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	9177220	GOA

Cellular Component GO Annotation	Evidence	Références	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	8387892	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11920585	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD70 Protein Structure

TNF

0
100
193 a.a.

Protein Preferred Names	Protein Names
CD70 antigen	CD27 ligand

CD70 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	CD70	P32970	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	CD70	P32970	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	CD70	P32970	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD70 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P72740	CD70 Protein, Human (HEK293, Fc)	P32970 (Q45-P193)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P75387	CD70 Protein, Human (Biotinylated, HEK293, Fc-Avi)	P32970-1 (Q39-P193)	≥ 80%, as determined by reducing SDS-PAGE.
HY-P78103	CD70 Trimer Protein, Human (Biotinylated, HEK293, His)	P32970-1 (L50-P193)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78540	FITC-Labeled CD70 Protein, Human (HEK293, His)	P32970-1 (L50-P193)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78560	CD70 Protein, Human (Biotinylated, HEK293, His-Avi&Flag)	P32970-1 (S52-P193)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700035AF	Animal-Free CD70 Protein, Human (His)	P32970-1 (Q39-P193)	≥ 95%, as determined by reducing SDS-PAGE.

CD70 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81664	CD70 Antibody (YA1409)	WB, FC, ELISA	Human
HY-P85005	CD70 Antibody (YA4697)	ELISA, FC	Human

Related Diseases

Diseases	Alias
Lymphoproliferative Syndrome 3	LPFS3 Cd70 Deficiency Combined Immunodeficiency Due To Cd70 Deficiency Cid Due To Cd70 Deficiency
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Lymphoproliferative Syndrome 2	Cd27 Deficiency LPFS2 Combined Immunodeficiency Due To Cd27 Deficiency Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency
Macroglobulinemia	Primary Macroglobulinemia Waldenstrom Macroglobulinemia
Lymphoproliferative Syndrome	Lymphoproliferative Disorder Lymphoproliferative Disorders Lymphoproliferative Disorders, Susceptibility To
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Immunodeficiency 20	Autosomal Recessive Primary Immunodeficiency With Defective Spontaneous Natural Killer Cell Cytotoxicity IMD20 Autosomal Recessive Primary Immunodeficiency With Defective Spontaneous Nk Cell Cytotoxicity Cd16 Deficiency Immunodeficiency, Type 20
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Immunodeficiency 16	Combined Immunodeficiency Due To Ox40 Deficiency IMD16 Ox40 Deficiency Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma Combined Immunodeficiency With Impaired Immunity To Hhv-8 Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8 Immunodeficiency, Type 16
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (3)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P99014	Cusatuzumab	Inhibitor	98.87%	Phase 2
HY-P99334	Vorsetuzumab mafodotin	Inhibitor	99.69%	Phase 1
HY-P991562	MDX-1411	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-160649	MC-Gly-Gly-Phe-Gly-GABA-Exatecan	Inhibitor	99.72%	Unkown
HY-178271	P-SCN-Bn-NOTA		95.0%	Unkown
HY-174736	Human CD70 mRNA		90%	Unkown
HY-185484	MDX-1203	Inhibitor	/	Unkown
HY-178257	Fmoc-Val-Lys-PAB-Exatecan		/	Unkown
HY-RS02264	CD70 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16751	Cd70 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23190	Cd70 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (8)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P99273	Vorsetuzumab	Inhibitor	99.29%	Unkown
HY-P990264	Anti-Mouse CD70 Antibody (FR70)	Inhibitor	95.00%	Unkown
HY-P990261	Anti-Mouse CD83 Antibody (Michel-17)	Inhibitor	98.722%	Unkown
HY-P991120	Balertatug	Inhibitor	98.84%	Unkown
HY-P99014A	Cusatuzumab (FUT8-KO)	Inhibitor	/	Unkown
HY-P991645	MDX-1115		98.86%	Unkown
HY-P991809	Anti-Mouse CD70 Antibody (TAN 1-7)	Inhibitor	/	Unkown
HY-P991930	ARX305 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CD70	VGNC	VGNC:38970
Macaca mulatta	CD70	VGNC	VGNC:70705
Mus musculus	CD70	MGD	MGI:1195273
Bos taurus	CD70	VGNC	VGNC:52225
Rattus norvegicus	CD70	RGD	RGD:1588573
Felis catus	CD70	VGNC	VGNC:60636
Others	CD70	NCBI