Heliquinomycin
Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth.
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- CAS No.: 178182-49-5
- Formule: C33H30O17
- Masse moléculaire:698.58
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Stockage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[2]|
Helicase |
Topoisomerase I |
Topoisomerase II |
In Vitro
Heliquinomycin (18 h) shows strong inhibitory activity against Gram-positive bacteria strains with MIC values of 0.1-0.39 μM[1].
Heliquinomycin inhibits the growth of HeLa S3, LI210 leukemia, IMC,carcinoma, B16 meranoma cells, with IC50s of 0-1.6 μg/mL[1].
Heliquinomycin (30 and 100 μg/mL) inhibits topoisomerase II and I enzymes activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 178182-49-5
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Appearance Solid
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Masse moléculaire 698.58
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Formule C33H30O17
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Color Brown to red
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SMILES
OC1=C([C@H]([C@]2(OC3=C(O)C(C(OC(C(OC)=O)=C4)=O)=C4C=C3C[C@H]2O)O5)O[C@H]6C[C@H]([C@H]([C@@H](O6)C)O)OC)C5=C(O)C(C(C(OC)=C7)=O)=C1C7=O
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Initial Source
Streptomyces sp. MJ929-SF2.
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Chino M, et al. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1996 Aug;49(8):752-7. [Content Brief]
[2]. Chino M,et al. Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth. J Antibiot (Tokyo). 1998 May;51(5):480-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Heliquinomycin Related Classifications
HY-105387 Related Classifications
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