Hexanoyl-coenzyme A
Hexanoyl coenzyme A is a short-chain fatty acyl-CoA thioester. Hexanoyl coenzyme A competes with butyryl-CoA to abolish the dehydrogenation effect of medium-chain acyl-CoA dehydrogenase on butyryl-CoA, and does not serve as a substrate for short-chain acyl-CoA dehydrogenase. Hexanoyl coenzyme A acts as a biosynthetic precursor for the synthesis of olivetolic acid and cannabinoids. Hexanoyl coenzyme A is applicable to research related to short-chain acyl-CoA dehydrogenase deficiency.
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- CAS No.: 5060-32-2
- Formule: C27H46N7O17P3S
- Masse moléculaire:865.68
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
Hexanoyl coenzyme A (0.8 mM) eliminates the interference of medium-chain acyl-CoA dehydrogenase (MCAD) in the activity assay of butyryl-CoA dehydrogenase, enabling specific and accurate determination of short-chain acyl-CoA dehydrogenase (SCAD) activity[1].
Hexanoyl coenzyme A is the direct precursor of cannabinoid biosynthesis and serves as its core initiating unit[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 5060-32-2
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Masse moléculaire 865.68
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Formule C27H46N7O17P3S
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SMILES
O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCCCC)=O)=O)=O)(O)=O)(O)=O)O[C@H]1N2C=NC3=C(N)N=CN=C32
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Synonyms
R-Hexanoyl-CoA; R-Hexanoyl coenzyme A
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Hexanoyl-coenzyme A
[2]. Niezen-Koning KE, et al. Measurement of short-chain acyl-CoA dehydrogenase (SCAD) in cultured skin fibroblasts with hexanoyl-CoA as a competitive inhibitor to eliminate the contribution of medium-chain acyl-CoA dehydrogenase. Clin Chim Acta. 1994;229(1-2):99-106. [Content Brief]
[3]. Stout JM, et al. The hexanoyl-CoA precursor for cannabinoid biosynthesis is formed by an acyl-activating enzyme in Cannabis sativa trichomes. Plant J. 2012;71(3):353-365. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hexanoyl-coenzyme A Related Classifications
HY-148869 Related Classifications
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Keywords
- Hexanoyl-coenzyme A
- 5060-32-2
- R-Hexanoyl-CoA
- R-Hexanoyl coenzyme A
- Biochemical Assay Reagents
- Drug Intermediate
- Endogenous Metabolite
- Cannabis sativa
- CsAAE1
- butyryl-CoA
- short-chain acyl-coa dehydrogenase deficiency
- olivetolic acid
- cannabinoids
- polyketide synthase
- medium-chain acyl-CoA dehydrogenase
- human skin fibroblasts
- short-chain acyl-CoA dehydrogenase
- Inhibitor
- inhibitor
- inhibit