L-783483
L-783483 (F3MethylAA) is an agonist for PPARδ. L-783483 ameliorates Carrageenan (HY-125474)-induced paw edema in mice.
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- CAS No.: 194608-77-0
- Formule: C22H21ClF3NO4S
- Masse moléculaire:487.92
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
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PPARδ |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
5900 nM
Compound: 1
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Activity at LXR alpha as beta-lactamase transactivation in CHO cells
Activity at LXR alpha as beta-lactamase transactivation in CHO cells
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[PMID: 16529931] |
| CHO | EC50 |
7300 nM
Compound: 1
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Activity at LXR beta as beta-lactamase transactivation in CHO cells
Activity at LXR beta as beta-lactamase transactivation in CHO cells
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[PMID: 16529931] |
| HEK293 | EC50 |
1080 nM
Compound: 1
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Effective concentration against liver X receptor-beta in HEK293 cell transactivation assay
Effective concentration against liver X receptor-beta in HEK293 cell transactivation assay
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[PMID: 15911262] |
| HEK293 | EC50 |
1790 nM
Compound: 1
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Effective concentration against liver X receptor-alpha in HEK293 cell transactivation assay
Effective concentration against liver X receptor-alpha in HEK293 cell transactivation assay
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[PMID: 15911262] |
Chemical Information
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CAS No. 194608-77-0
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Masse moléculaire 487.92
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Formule C22H21ClF3NO4S
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SMILES
O=C(CC1=CC=C(C(Cl)=C1)SCCCOC2=C(CCC)C(ON=C3C(F)(F)F)=C3C=C2)O
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Synonyms
F3MethylAA
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Carrageenan-Induced Paw Edema
Carrageenan-induced paw edema is an acute inflammation model in which intraplantar injection of carrageenan induces localized inflammatory swelling characterized by vascular permeability, leukocyte infiltration, and production of inflammatory mediators such as prostaglandins and cytokines, making it widely used to evaluate anti-inflammatory agents in vivo. The resulting paw volume or thickness increase is quantified over time as a direct readout of inflammatory intensity and drug efficacy, typically reflecting cyclooxygenase-mediated prostaglandin-driven edema formation and immune cell recruitment in peripheral tissue[20].
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-783483 Related Classifications
HY-116597 Related Classifications
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