m7GpppAmpG
m7GpppAmpG (m7G(5')ppp(5')(2'OMeA)pG) is a trinucleotide 5′ cap analog. m7GpppAmpG binds to eIF4E with a KD value of 45.6 nM. m7GpppAmpG caps RNA with an efficiency of 90% and enhances mRNA stability and translation efficiency. m7GpppAmpG is used in mRNA therapeutic research.
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- CAS No.: 62858-30-4
- Formule: C32H43N15O24P4
- Masse moléculaire:1145.66
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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eIF4E 45.6 nM (Kd) |
Chemical Information
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CAS No. 62858-30-4
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Masse moléculaire 1145.66
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Formule C32H43N15O24P4
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](OC)[C@H](OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(N)=N6)=O)[C@H](O)[C@@H]4O)(O)=O)[C@@H](COP(OP(OP(OC[C@H]7O[C@@H](N(C=[N+]8C)C9=C8C(N=C(N)N9)=O)[C@H](O)[C@@H]7O)([O-])=O)(O)=O)(O)=O)O3
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Synonyms
m7G(5')ppp(5')(2'OMeA)pG
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Sikorski PJ, Warminski M, Kubacka D, et al. The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5' cap modulates protein expression in living cells. Nucleic Acids Res. 2020;48(4):1607-1626. [Content Brief]
[3]. Raab M, et al. Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancer. Cancer Commun (Lond). 2024 Jan;44(1):101-126. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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