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MPP+ iodide

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Based on 37 publication(s) in Google Scholar

MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT).

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  • Pureté: 99.96%
  • CAS No.: 36913-39-0
  • Formule: C12H12IN
  • Masse moléculaire:297.14
  • Stockage:

    4°C, sealed storage, away from moisture and light

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • MPP+ iodide Chemical Structure
    MPP+ iodide Chemical Structure
  • Experimental Validation Results for MPP+ iodide
  • Experimental Validation Results for MPP+ iodide
  • Experimental Validation Results for MPP+ iodide
  • Experimental Validation Results for MPP+ iodide
  • Experimental Validation Results for MPP+ iodide
  • Experimental Validation Results for MPP+ iodide
  • Experimental Validation Results for MPP+ iodide
CAS No.: 36913-39-0
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  • MPP+ iodide Chemical Structure
    MPP+ iodide Chemical Structure
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    MPP+ iodide purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Jul 29;11(1):351. [Abstract]

    Customer Validation
     SH-SY5Y cells were treated for 24 h with 1 μM MPP (MPP+ iodide). Bright field images of cells in the PD cell model.

  • 1/16

    MPP+ iodide purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Jul 29;11(1):351. [Abstract]

    Customer Validation
     SH-SY5Y cells were treated for 24 h with 1 μM MPP (MPP+ iodide). Representative images (left) and ratios (right) of TUNEL+ cells in PD cell model.

  • 1/16

    MPP+ iodide purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Jul 29;11(1):351. [Abstract]

    Customer Validation
     SH-SY5Y cells were treated for 24 h with 1 μM MPP (MPP+ iodide). Representative images of flow cytometric analysis of MMP in PD cell model (left), median fluorescence intensity (MFI; middle), and the proportion of high MMP (H-MMP) to total cell number (right).

  • 1/16

    MPP+ iodide purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Nov 10;22(1):690. [Abstract]

    Customer Validation
     CCK8 assay of SH-SY5Y cells treated with MPP+ (MPP+ iodide, 1 mM; 24 h) and purified melanin.

  • 1/16

    MPP+ iodide purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Nov 10;22(1):690. [Abstract]

    Customer Validation
     Typical JC-1 staining (Left) and TMRE staining (Right) of MPP+- (MPP+ iodide, 1 mM , 12 h) treated SH-SY5Y cells that were co-cultured with E. coli with distinct pretreatments.

  • 1/16

    MPP+ iodide purchased from MedChemExpress. Usage Cited in: Neurochem Res. 2023 Jul;48(7):2129-2137. [Abstract]

    Customer Validation
     MPP+ iodide (MPP+; 0, 0.2, 0.4, 0.6, 0.8, 1, 2 mM; 48 h) decreases viability of SH-SY5Y cells (Fig D). At a concentration of 0.6 mM, MPP+ iodide decreases the cell viability by 25%. Moreover, the IC50 value of MPP+ iodide on SH-SY5Y cells is 1.233 mM (Fig C).

  • 1/16

    MPP+ iodide purchased from MedChemExpress. Usage Cited in: Neurochem Res. 2023 Jul;48(7):2129-2137. [Abstract]

    Customer Validation
     MPP+ iodide (MPP+; 1.2 mM; 48 h) decreases TH, Prdx-2, SIRT1 protein levels and increases the ratio of Bax / Bcl-2, in SH-SY5Y cells.

  • MPP+ iodide