NNMT-IN-3
NNMT-IN-3 (Compound 14) is a potent and selective nicotinamide N-methyltransferase (NNMT) inhibitor, with IC50 values of 1.1 nM and 0.4 μM in cell-free and cell-based assays, respectively. NNMT-IN-3 can be used in the research of diseases such as obesity, type 2 diabetes and cancer.
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- CAS No.: 3031493-74-7
- Formule: C34H34ClN7O
- Masse moléculaire:592.13
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
IC50: 1.1 nM (NNMT, cell-free), 0.4 μM (NNMT, cell-based)[1]
In Vitro
NNMT-IN-3 (22-24 h) potently inhibits recombinant human NNMT in cell-free assays, with an IC50 of 0.0011 μM[1].
NNMT-IN-3 inhibits NNMT activity in NNMT-overexpressing HEK293 cells, with an IC50 of 0.40 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3031493-74-7
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Appearance Solid
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Masse moléculaire 592.13
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Formule C34H34ClN7O
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Color Off-white to light yellow
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SMILES
CC1=CC=C2C(C=C(N2CC3=CC=C(C=C3)Cl)[C@H]4C[C@@H](CN4C(C5=CC6=C(NC(C)=C6)N=C5)=O)N7N=C(C=C7CN)C)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NNMT-IN-3 Related Classifications
HY-151193 Related Classifications
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