country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-122101

Copy Link Print Information

NSC114792

NSC114792 is a selective JAK3 inhibitor. NSC114792 induces apoptosis. NSC114792 decreases the protein expression of p-JAK3 and p-STAT5.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 17392-79-9
Formule: C₂₆H₃₂N₄O₂S
Masse moléculaire:464.62

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

NSC114792 Chemical Structure

CAS No.: 17392-79-9

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

NSC114792 is a selective JAK3 inhibitor. NSC114792 induces apoptosis. NSC114792 decreases the protein expression of p-JAK3 and p-STAT5^[1].

IC₅₀ & Target^[1]

JAK3

Voir tous les produits spécifiques à Isoform JAK :

In Vitro

NSC114792 (0, 5, 10, 20 µM; 24, 48, 72 h) inhibits BaF3-JAK3^V674A and BKO84 cell viability in a time and dose-dependent manner^[1].
NSC114792 (0, 5, 10, 20 µM) decreases the protein expression of p-JAK3 and p-STAT5 in a dose-dependent manner^[1].
NSC114792 (0, 5, 10, 20 µM; 72 h) induces apoptosis in a dose-dependent manner in L540 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

L540, HDLM-2, MDA-MB-468, DU145 cells
Concentration:

0, 5, 10, 20 µM
Incubation Time:

0, 24, 48, 72 h
Result:

Inhibited cell viability in a time and dose-dependent manner.

Western Blot Analysis^[1]

Cell Line:

BKO84 cells
Concentration:

0, 5, 10, 20 µM
Incubation Time:
Result:

Decreased the protein expression of p-JAK3 and p-STAT5 in a dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

L540 cells
Concentration:

0, 10, 20 µM
Incubation Time:

72 h
Result:

Induced apoptosis and increased the expression of cleaved PARP and cleaved Capase-3, decreased the protein expression of Bcl-2, Bcl-Xl, Mcl-1, Survivin in a dose-dependent manner.

Chemical Information

CAS No. 17392-79-9
Masse moléculaire 464.62
Formule C₂₆H₃₂N₄O₂S
SMILES

C[C@@]12[C@@H](C(CN3C=NC4=C3N=CNC4=S)=O)CC[C@@]1([H])[C@]5([H])CCC6=CC(CC[C@]6(C)[C@@]5([H])CC2)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kim BH, et al. NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3. Mol Cancer. 2010 Feb 11;9:36. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

NSC114792

Voir tous les produits spécifiques à Isoform JAK

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

NSC114792 Related Classifications

HY-122101 Related Classifications