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Onvatilimab

(Synonyms: JNJ-61610588; CI-8993; VSTB112)
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Based on 1 publication(s) in Google Scholar

Onvatilimab (JNJ-61610588) is a human IgG1κ anti-VISTA (V-domain Ig Suppressor of T-cell Activation) monoclonal antibody. Onvatilimab can be used in colorectal cancer research.

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  • Pureté: 98.00%
  • CAS No.: 1969313-51-6
  • Masse moléculaire:144.52 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Onvatilimab
  • Experimental Validation Results for Onvatilimab
  • Experimental Validation Results for Onvatilimab
  • Onvatilimab Chemical Structure
    Onvatilimab Chemical Structure
CAS No.: 1969313-51-6
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609-228-6898
[email protected] [email protected]
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Loaded VISTA/B7-H5 Protein, Human (HEK293, Fc, HY-P77879) on SA biosensor, can bind Onvatilimab with an affinity constant of 2.039E-10 M as determined in BLI assay.

  • 1/16

    Flow cytometric analysis of 106 Jurkat cells labeling Onvatilimab (HY-P99040, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor® 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Onvatilimab Chemical Structure
    1/16
  • Onvatilimab
  • Loaded VISTA/B7-H5 Protein, Human (HEK293, Fc, HY-P77879) on SA biosensor, can bind Onvatilimab with an affinity constant of 2.039E-10 M as determined in BLI assay.
  • Flow cytometric analysis of 106 Jurkat cells labeling Onvatilimab (HY-P99040, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor® 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).