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Pasritamig

(Synonyms: JNJ-78278343; KLCB-245)
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Pasritamig (JNJ-78278343; KLCB-245) is a bispecific T-cell engager (BiTE) targeting the human kallikrein KLK2 and CD3 receptor complex. Pasritamig directs T-cell cytotoxicity toward KLK2-expressing tumor cells and induces T cell-mediated lysis of KLK2-expressing prostate cancer cells. Pasritamig can be used in research on metastatic castration-resistant prostate cancer.

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  • Pureté : 99.97%
  • CAS No.: 2921676-04-0
  • Masse moléculaire:124.81 kDa
  • Stockage:
    Shipping with dry ice

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Pasritamig
  • Experimental Validation Results for Pasritamig
  • Experimental Validation Results for Pasritamig
  • Experimental Validation Results for Pasritamig
  • Pasritamig Chemical Structure
    Pasritamig Chemical Structure
CAS No.: 2921676-04-0
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Pasritamig Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    G1-kappa_scFv-h-CH2-CH3

  • 1/16

    Immobilized Kallikrein-2 Protein, Human (HEK293, His, HY-P70317) can bind Pasritamig. The EC50 for this effect is 53.53 ng/mL.

  • 1/16

    Immobilized CD3 epsilon Protein, Human (HEK293, His,HY-P70506) can bind Pasritamig. The EC50 for this effect is 791.3 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 Juakat cells with Pasritamig (HY-P991015, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Pasritamig Chemical Structure
    1/16
  • Pasritamig
  • Immobilized Kallikrein-2 Protein, Human (HEK293, His, HY-P70317) can bind Pasritamig. The EC50 for this effect is 53.53 ng/mL.
  • Immobilized CD3 epsilon Protein, Human (HEK293, His,HY-P70506) can bind Pasritamig. The EC50 for this effect is 791.3 ng/mL.
  • Flow cytometric analysis of 1X106 Juakat cells with Pasritamig (HY-P991015, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • G1-kappa_scFv-h-CH2-CH3