Phaseic acid
Based on 1 publication(s) in Google Scholar
Phaseic acid is a Abscisic acid terpenoid catabolite that can able to activate a subset of Abscisic acid repectors. Phaseic acid is a plant hormone associated with photosynthesis arrest and abscission. Phaseic acid is the antagonist for NMDA-type glutamate receptor (NMDAR) that inhibits NMDAR currents with an IC50 of 34.37 μM. Phaseic acid reduces intracellular calcium influx, and exhibits neuroprotective effect.
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- Pureté: 98.76%
- CAS No.: 24394-14-7
- Formule: C15H20O5
- Masse moléculaire:280.32
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Stockage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Phaseic acid
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Activité biologique
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Cell Line
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Type | Value | Description | References |
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| BV-2 | IC50 |
>10 μM
Compound: 21
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Antiinflammatory activity in C57BL6/J mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antiinflammatory activity in C57BL6/J mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
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[PMID: 26110443] |
| MDCK | IC50 |
>35 μM
Compound: 21
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Antiviral activity against Influenza A virus (A/FM/1/47(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect
Antiviral activity against Influenza A virus (A/FM/1/47(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect
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[PMID: 26110443] |
| Vero | IC50 |
>35 μM
Compound: 21
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Antiviral activity against Coxsackievirus B3 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect
Antiviral activity against Coxsackievirus B3 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect
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[PMID: 26110443] |
Phaseic acid (10 µM, 3 h) promotes the stomatal closure, reduces water evaporation in Commelina communis leaves[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse cerebral artery occlusion (MCAO) models[2]
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Dosage:50 mg/mL
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Administration:intraventricular injection, continuous infusion for 3 days
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Result:Reduced the volume of ischemic brain lesions.
Chemical Information
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CAS No. 24394-14-7
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Appearance Solid
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Masse moléculaire 280.32
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Formule C15H20O5
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Color White to off-white
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SMILES
O=C(O)/C=C(C)\C=C\[C@]1(O)[C@]2(C)CC(C[C@@]1(C)OC2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Agric Food Chem
Development of an Ultrahigh-Performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry Method for Multiclass Phytohormone Quantification Via Multifunctional Chemical Derivatization. [Abstract]2026 May 27;74(20):15910-15920. PMID: 42145237
Pureté et documentation
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Fiche technique (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Pedro L Rodriguez, et al. Abscisic Acid Catabolism Generates Phaseic Acid, a Molecule Able to Activate a Subset of ABA Receptors. Mol Plant. 2016 Nov 7;9(11):1448-1450. [Content Brief]
[2]. Hou ST, et al., Phaseic Acid, an Endogenous and Reversible Inhibitor of Glutamate Receptors in Mouse Brain. J Biol Chem. 2016 Dec 30;291(53):27007-27022. [Content Brief]
[3]. Sharkey TD, et al., Effects of phaseic Acid and dihydrophaseic Acid on stomata and the photosynthetic apparatus. Plant Physiol. 1980 Feb;65(2):291-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phaseic acid Related Classifications
HY-111973 Related Classifications
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