PluriSIn #2
Based on 3 publication(s) in Google Scholar
PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs).
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- Pureté: 98.0%
- CAS No.: 56563-17-8
- Formule: C11H8FN3O3
- Masse moléculaire:249.20
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Stockage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) PluriSIn #2
MoreVoir tous les produits spécifiques à Isoform Topoisomerase
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Activité biologique
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topoisomerase II alpha |
PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level[1].
A 24h exposure of PluriSIn #2 (20 µM) is sufficient to induce massive cell death in hPSCs, but doesn’t affect the viability of various other cell types derived from them[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:B153 and HUES9 human pluripotent stem cells (hPSCs)
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Concentration:20 µM
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Incubation Time:12 hours
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Result:Reduced TOP2A expression at the protein level.
Chemical Information
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CAS No. 56563-17-8
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Appearance Solid
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Masse moléculaire 249.20
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Formule C11H8FN3O3
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Color White to off-white
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SMILES
O=C(N(C(N1)=O)C=C(F)C1=O)NC2=CC=CC=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (3)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Scopoletin alleviates cognitive deficits in 5xFAD mice via suppressing microglial inflammatory response. [Abstract]2026 Apr:153:157981. PMID: 41722121 -
Mol Med
TOP2A deficiency leads to human recurrent spontaneous abortion and growth retardation of mouse pre-implantation embryos. [Abstract]2022 Dec 30;28(1):165. PMID: 36585615 -
J Inflamm Res
Exploring The Role of TOP2A in the Intersection of Pathogenic Mechanisms Between Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis Based on Bioinformatics. [Abstract]2025 Mar 11:18:3449-3468. PMID: 40093950
Solvant et solubilité
DMSO : 5 mg/mL (20.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 4.0128 mL | 20.0642 mL | 40.1284 mL | 100.3210 mL |
| 5 mM | 0.8026 mL | 4.0128 mL | 8.0257 mL | 20.0642 mL | |
| 10 mM | 0.4013 mL | 2.0064 mL | 4.0128 mL | 10.0321 mL | |
| 15 mM | 0.2675 mL | 1.3376 mL | 2.6752 mL | 6.6881 mL | |
| 20 mM | 0.2006 mL | 1.0032 mL | 2.0064 mL | 5.0161 mL |
PluriSIn #2 Related Classifications
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