Procumbenoside A
Procumbenoside A is a lignan glycoside discovered in Justicia procumbens. Procumbenoside A inhibits HIV-1 replication with an IC50 of 4.95 μM. Procumbenoside A exerts cytotoxic effects on various cancer cells. Procumbenoside A induces Cu (II)-mediated strand breaks in supercoiled plasmid DNA, generating the relaxed circular DNA form, while no linear form is detected. Procumbenoside A is used in studies related to liver cancer, colon adenocarcinoma, and HIV-1 infection.
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- CAS No.: 408358-51-0
- Formule: C31H32O15
- Masse moléculaire:644.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
HIV-1 4.95 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | ED50 |
3.1 μg/mL
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Cytotoxic activity against 212 cells measured by MTT assay after 6 days of incubation.
Cytotoxic activity against 212 cells measured by MTT assay after 6 days of incubation.
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11908984 |
| Hep 3B2 | ED50 |
3.1 μg/mL
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Cytotoxic activity against human Hep 3B cells measured by MTT assay after 6 days of incubation.
Cytotoxic activity against human Hep 3B cells measured by MTT assay after 6 days of incubation.
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11908984 |
| HepG2 | ED50 |
3.9 μg/mL
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Cytotoxic activity against human Hep G2 cells measured by MTT assay after 6 days of incubation.
Cytotoxic activity against human Hep G2 cells measured by MTT assay after 6 days of incubation.
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11908984 |
| HT-29 | ED50 |
6.7 μg/mL
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Cytotoxic activity against human HT-29 cells measured by MTT assay after 6 days of incubation.
Cytotoxic activity against human HT-29 cells measured by MTT assay after 6 days of incubation.
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11908984 |
| A549 | CC50 |
> 31.0 μM
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Cytotoxicity against human A549 lung epithelial cells assessed by MTS assay at 48 h after initial compound addition following 24 h incubation with procumbenoside A, with the CC50 value greater than 31.0 μM.
Cytotoxicity against human A549 lung epithelial cells assessed by MTS assay at 48 h after initial compound addition following 24 h incubation with procumbenoside A, with the CC50 value greater than 31.0 μM.
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31882050 |
In Vitro
Procumbenoside A (6 days) exerts significant cytotoxic effects on 212, Hep 3B, Hep G2, and HT-29 cells, with ED50 values of 3.1, 3.1, 3.9, and 6.7 µg/mL, respectively[1].
Procumbenoside A (0.3125-10 μM; 24-48 h) inhibits the replication of HIV-1 pseudovirus in A549 human lung epithelial cells, with an IC50 of 4.95 μM. It exhibits low cytotoxicity (CC50 > 31.0 μM) and a selectivity index greater than 6.2[2].
Procumbenoside A significantly induces Cu (II)-mediated concentration-dependent strand breaks in supercoiled pBR322 plasmid DNA, resulting in the formation of relaxed open-circle DNA[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 human lung epithelial cells
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Concentration:0.3125, 0.625, 1.25, 2.5, 5 and 10 μM
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Incubation Time:24 h
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Result:Exhibited low cytotoxicity (CC50 > 31.0 μM).
Chemical Information
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CAS No. 408358-51-0
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Masse moléculaire 644.58
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Formule C31H32O15
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SMILES
O=C1C2=C(C=3C(C(O[C@H]4[C@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O)CO5)[C@](CO)(O)CO4)=C2CO1)=CC(OC)=C(OC)C3)C=6C=C7C(=CC6)OCO7
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Structure Classification
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Day SH, et al. Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages. Journal of natural products. 2002 Mar;65(3):379-81. [Content Brief]
[2]. Xu XY, et al. Anti-HIV lignans from Justicia procumbens. Chinese journal of natural medicines. 2019 Dec;17(12):945-952. [Content Brief]
[3]. Lu YH, et al. DNA strand-scission by phloroglucinols and lignans from heartwood of Garcinia subelliptica Merr. and Justicia plants. Phytochemistry. 2008 Jan;69(1):225-33. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Procumbenoside A Related Classifications
HY-N21692 Related Classifications
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