BTLA
B and T cell lymphocyte attenuator (BTLA; CD272) is an inhibitory receptor that belongs to the B7-CD28 family. BTLA is structurally and functionally related to CTLA-4 and PD-1 and can be identified on most lymphocytes, such as T and B lymphocytes, macrophages, dendritic cells, and nature killer (NK) cells. The BTLA ligand, herpesvirus entry mediator (HVEM, also called TNFRSF14), is a member of the tumor necrosis factor receptor (TNFR) superfamily. Ligation of BTLA by HVEM induces tyrosine phosphorylation of ITIM in BTLA and subsequent recruitment of the protein tyrosine phosphatases SHP-1/SHP-2, and then exerts direct negative effects on the proliferation and activation of B and T cells. BTLA participates in numerous physiopathological processes, such as tumor, inflammatory diseases, autoimmune diseases, infectious diseases, and transplantation rejection.
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BTLA Recombinant Proteins (11)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
