QNX-10
QNX-10 is a fatty acid synthase (FASN) inhibitor (IC50 = 0.7 μM) with anticancer activity. QNX-10 exhibits potent FASN inhibition and cytotoxicity against colorectal and breast cancer cells. QNX-10 induces apoptosis and cell cycle arrest in S phase by upregulating the pro-apoptotic protein Bax and downregulating the anti-apoptotic protein Bcl-xL. QNX-10 can be used to investigate anticancer therapies targeting FASN enzymes.
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- Formule: C24H23FN4O3
- Masse moléculaire:434.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Bax |
Bcl-xL |
QNX-10 (0-10 μM, 48 h) exhibits cytotoxicity against HCT-116, Caco-2, and MCF-7 cells with IC50 of 1.5 μM, 2.1 μM, and 1.8 μM, respectively, and has no toxicity to HEK-293 cells, with an IC50 of 30.4 μM[1].
QNX-10 (0.5-2.5 μM, 48 h) inhibits cell cycle progression by inducing S phase cell cycle arrest in HCT-116 cells[1].
QNX-10 (0.5-2.5 μM) increases Bax and decreased Bcl-xL and FASN levels, exhibiting dose-dependent apoptotic properties in HCT-116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116 cells
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Concentration:0.5 μM, 1.5 μM , 2.5 μM
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Incubation Time:48 h
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Result:Induced cell cycle arrest in S phase, resulting in 23.3% and 28.6% accumulation of the population in S phase at 1.5 μM and 2.5 μM, respectively, and increased the G2/M population by 27.5% and 29.4% after 1.5 μM and 2.5 μM QNX-10 exposure, respectively.
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Cell Line:HCT-116 cells
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Concentration:0.5 μM, 1.5 μM , 2.5 μM
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Incubation Time:48 h
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Result:Increased the number of cell death cells, induced cell death in 15.4% of the cell population (10.93% apoptotic cells + 4.47% necrotic cells) at 0.5 μM, increased the dead cell population to 39.2% (31.6% apoptotic cells + 7.6% necrotic cells) at 1.5 μM, and induced cell death to 61.1% at 2.5 μM, of which 49.73% of the cells underwent apoptosis and 11.37% underwent necrosis.
Chemical Information
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Masse moléculaire 434.46
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Formule C24H23FN4O3
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SMILES
FC1=CC=C(C2=CN=C(C=C(C(N3CCN(C(C4OCCC4)=O)CC3)=O)C=C5)C5=N2)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
QNX-10 Related Classifications
HY-175020 Related Classifications
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