Rpi-856 C
Rpi-856 C is an Aspartic protease inhibitor, with an IC50 of 5.5 nM against HIV-1 protease, 9.2 nM against HTLV-I protease, 2.0 μM against Cathepsin D, and 4.8 μM against Pepsin. Rpi-856 C is produced by the Streptomyces strain AL-322. Rpi-856 C does not inhibit chymosin, trypsin, chymotrypsin, papain, bromelain, thermolysin, prolyl endopeptidase, carboxypeptidase A or carboxypeptidase B. Rpi-856 C can be used in the research of acquired immunodeficiency syndrome (AIDS) and related diseases, as well as HIV infection.
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- CAS No.: 157381-55-0
- Formule: C39H56N6O10
- Masse moléculaire:768.90
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
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Cathepsin D 2.0 μM (IC50) |
HIV-1 Protease 5.5 nM (IC50) |
Microbial Metabolite |
In Vitro
Rpi-856 C (3 h) potently inhibits recombinant HIV-1 protease derived from Escherichia coli MM294 (DE3)/pHIV7004, with an IC50 value of 5.5 nM[1].
Rpi-856 C inhibits recombinant HTLV-I protease derived from Escherichia coli MM294 (DE3)/pHTI7707, with an IC50 value of 9.2 nM[1].
Rpi-856 C inhibits bovine cathepsin D with an IC50 value of 2.0 μM[1].
Rpi-856 C exhibits inhibitory activity against porcine pepsin, with an IC50 value of 4.8 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 157381-55-0
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Masse moléculaire 768.90
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Formule C39H56N6O10
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Sequence
V-{Gly(2-(3,5-dihydroxyphenyl))}-L-{2-oxo-4-phenyl-3-aminobutanoyl}-VV
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Sequence Shortening
Val-{Gly(2-(3,5-dihydroxyphenyl))}-Leu-{2-oxo-4-phenyl-3-aminobutanoyl}-Val-Val
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rpi-856 C Related Classifications
HY-P1982 Related Classifications
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Keywords
- Rpi-856 C
- 157381-55-0
- HIV Protease
- Cathepsin
- Endogenous Metabolite
- Escherichia coli MM294 (DE3)/pHIV7004
- bovine cathepsin D
- HTLV-I protease
- acquired immunodeficiency syndrome
- porcine pepsin
- Streptomyces sp. AL-322
- aspartic protease
- human immunodeficiency virus infection
- Escherichia coli MM294 (DE3)/pHTI7707
- HIV-1 protease
- Inhibitor
- inhibitor
- inhibit