SCP-7
SCP-7 is a STAT3 inhibitor with a Kd value of 795 nM. SCP-7 induces mitochondrial dysfunction, increases ROS levels and promotes apoptosis. SCP-7 induces G2/M phase arrest of the cell cycle. SCP-7 inhibits the proliferation, migration and colony formation of colorectal cancer cells. SCP-7 suppresses tumor growth in a mouse xenograft model of colorectal cancer. SCP-7 is applicable to research related to colorectal cancer.
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- CAS No.: 2479389-64-3
- Formule: C22H20O6
- Masse moléculaire:380.39
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
STAT3 795 nM (Kd) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
3.84 μM
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Inhibition of cell viability against human HCT116 cells incubated for 48 hrs by MTT assay.
Inhibition of cell viability against human HCT116 cells incubated for 48 hrs by MTT assay.
|
42497765 |
| HT-29 | IC50 |
1.58 μM
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Inhibition of cell viability against human HT29 cells incubated for 48 hrs by MTT assay.
Inhibition of cell viability against human HT29 cells incubated for 48 hrs by MTT assay.
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42497765 |
| HEK-293T | IC50 |
18.34 μM
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Inhibition of cell viability against human HEK-293T cells incubated for 48 hrs by MTT assay.
Inhibition of cell viability against human HEK-293T cells incubated for 48 hrs by MTT assay.
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42497765 |
In Vitro
SCP-7 (48 h) potently inhibits the viability of HCT116 and HT29 colorectal cancer cells with IC50 values of 3.84 μM and 1.58 μM, respectively, and exhibits reduced activity against normal HEK-293T cells[1].
SCP-7 (48 h) inhibits the proliferation of HCT116 and HT29 colorectal cancer cells[1].
SCP-7 (72 h) concentration-dependently inhibits colony formation by HCT116 and HT29 colorectal cancer cells[1].
SCP-7 (0.25 μM-1 μM; 12 h, 24 h) inhibits the migration of HCT116 and HT29 colorectal cancer cells[1].
SCP-7 (48 h) induces apoptosis in HCT116 and HT29 colorectal cancer cells, as evidenced by increased apoptotic cell proportions and altered expression of BAX, Bcl-2, Mcl-1, and survivin[1].
SCP-7 (2.5 μM-10 μM; 48 h) induces mitochondrial dysfunction and oxidative stress in HCT116 and HT29 colorectal cancer cells[1].
SCP-7 (2.5 μM-10 μM; 48 h) induces G2/M phase cell cycle arrest in HCT116 and HT29 colorectal cancer cells, accompanied by reduced cyclin B1 and CDK1 expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116, HT29
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Concentration:0, 0.5, 1 and 2 μM
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Incubation Time:12 h, 24 h
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Result:Inhibited the migration.
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Cell Line:inhibits the migration
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Concentration:0, 2.5, 5 and 10 μM
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Incubation Time:48 h
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Result:Induced cell apoptosis.
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Cell Line:inhibits the migration
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Concentration:0, 0.625, 1.25, 2.5, 5 and 10 μM
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Incubation Time:48 h
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Result:Upregulated BAX.
Downregulated Bcl-2, Mcl-1, survivin and c-Myc.
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Cell Line:HCT116, HT29
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Concentration:0, 2.5, 5 and 10 μM
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Incubation Time:48 h
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Result:Increased the proportion of cells in the G2/M phase in a concentration-dependent manner in both HCT116 and HT29 cells.
Significantly reduced cyclin B1 and CDK1 expression levels in both cell lines.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice[1]
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Dosage:2.5 mg/kg; 5 mg/kg
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Administration:i.p.; once every two days; 14 days
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Result:Suppressed HCT116 xenograft tumor growth in a dose-dependent manner.
Reduced tumor weight and volume significantly compared to the control group.
Reduced Ki67 and p-STAT3 levels in tumor tissue.
Increased BAX levels in tumor tissue.
Downregulated downstream STAT3 targets c-Myc and Bcl-2.
Caused no significant changes in mouse body weight during treatment.
Showed no significant toxicity via organ index analysis, H&E staining of major organs, and serum levels of ALT, AST, CRE, and TBIL.
Chemical Information
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CAS No. 2479389-64-3
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Masse moléculaire 380.39
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Formule C22H20O6
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SMILES
O=C(C1=CC=CC=C1)O[C@@H]2/C=C(C)/C[C@H](OC3=O)C=C3C[C@H]4[C@H]2C(C(O4)=O)=C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SCP-7 Related Classifications
HY-187792 Related Classifications
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