country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-181828

Copy Link Print Information

SePP

SePP is a blood-brain barrier-permeable NMDAR antagonist and dopamine/norepinephrine reuptake inhibitor, with a K_i of 28.7 nM for rat NMDAR. SePP exerts anticonvulsant effects. SePP can be used in research related to fragile X syndrome.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₁₇H₂₁NSe
Masse moléculaire:318.32

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SePP Chemical Structure

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

NMDA Receptor

28.7 nM (Ki)

Voir tous les produits spécifiques à Isoform iGluR :

Voir tous les produits spécifiques à Isoform Dopamine Receptor :

In Vitro

SePP (multiple concentrations; 2 h) potently binds to rat forebrain NMDARs with a K_i of 28.7 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	Plasma Concentration
Mice^[1]	10 mg/kg	i.p.	387.5 ng/mL

In Vivo

SePP (10 mg/kg; i.p.) completely suppresses audiogenic seizures in juvenile Fmr1 knockout mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

FVB.129P2-Pde6b+ Tyrc‑ch Fmr1tm1Cgr/J (Fmr1 knockout, 4 male and 4 female, postnatal day 23-25, audiogenic seizure induction)^[1]
Dosage:

10 mg/kg
Administration:

i.p.; single dose
Result:

Abolished wild running and jumping (WRJ), tonic-clonic seizure (TCS), and respiratory arrest (RA) in all treated mice, with statistically significant differences compared to vehicle controls (P < 0.0001 for WRJ and TCS, P = 0.0013 for RA).
Exhibited normal behaviors including exploring, rearing, grooming, and interacting with cage-mates during testing.

Chemical Information

Masse moléculaire 318.32
Formule C₁₇H₂₁NSe
SMILES

C1(CC(N2CCCCC2)C3=CC=C[Se]3)=CC=CC=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Wallach J, et al. Bioisostere-Driven Discovery of SePP: A Selenium-Containing Polypharmacological Agent Relevant to Fragile X Syndrome. J Med Chem. 2026;69(4):4020-4036. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

SePP

Voir tous les produits spécifiques à Isoform iGluR

Voir tous les produits spécifiques à Isoform Dopamine Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SePP Related Classifications

HY-181828 Related Classifications