Serrumab
Serrumab is a human monoclonal antibody that counteracts the biochemical and immunological effects of Tityus serrulatus venom. Serrumab inhibits the TsV-induced increase in the production of IL-6, TNFα and IL-10. Serrumab also prevents TsV-induced elevations in plasma urea, creatinine, aspartate transaminase and glucose levels, as well as the TsV-induced increase in neutrophil recruitment. Serrumab can be used in research related to envenoming by the Brazilian yellow scorpion.
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
Human IgG1 kappa
Tityus serrulatus
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IL-6 |
IL-10 |
Serrumab (10-20 μg/mL; 60 min pre-incubation with TsV, 24 h incubation with cells) inhibits TsV-induced IL-6 and TNF-α production in J774.1 murine peritoneal macrophages, with 10 μg/mL also inhibiting TsV-induced IL-10 production[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (male, 15-25 g)[1]
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Dosage:10 µg per animal; 20 µg per animal
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Administration:injection
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Result:Prevented venom-induced increases in plasma urea, creatinine, and aspartate transaminase (AST) levels, with values not significantly different from control mice.
Prevented venom-induced increases in neutrophil recruitment, with neutrophil percentages matching control levels.
Prevented venom-induced hyperglycemia (observed 1-4 hours post-venom injection) and subsequent hypoglycemia (observed 5 hours post-venom injection), maintaining glucose levels within the normal control range over the 24-hour monitoring period.
Tityustoxin VIIToxin VIITs7
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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SMILES
[Serrumab]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Serrumab Related Classifications
HY-P992153 Related Classifications
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