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Cat. No.: HY-W745845

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Simendan

Name: Simendan
Brand: MedChemExpress
SKU: HY-W745845
Availability: PreOrder

(Synonyms: (rac)-Levosimendan; (rac)-Simsndan; (rac)-OR-1259)

Simendan ((rac)-Levosimendan; (rac)-Simsndan; (rac)-OR-1259) is a calcium-sensitizing positive inotropic vasodilator compound that enhances myocardial contractility through calcium-dependent binding to cardiac troponin C and selectively inhibits cardiac phosphodiesterase (Phosphodiesterase) III, while inducing coronary and peripheral vasodilation and anti-ischemic effects. Simendan can be used for research on congestive heart failure, acute heart failure, myocardial infarction, myocardial ischemia, and thrombotic diseases.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 131741-08-7
Formule: C₁₄H₁₂N₆O
Masse moléculaire:280.28

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Simendan Chemical Structure

CAS No.: 131741-08-7

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE) :

In Vitro

Simendan ((rac)-Levosimendan; (rac)-Simsndan; (rac)-OR-1259) selectively inhibits cardiac phosphodiesterase III in purified enzyme preparations^[1].
Simendan binds to cardiac troponin C in a calcium-dependent manner in paced papillary muscle preparations, combining positive inotropic effects with enhanced cardiac relaxation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

Simendan ((rac)-Levosimendan; (rac)-Simsndan; (rac)-OR-1259) (2.5 mg/kg; p.o.; free access; 312 days) improves survival in rats with post-myocardial infarction healing, with a mortality rate of 53% at 312 days, representing a 28% risk reduction compared with the control group^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (Male, 300-350 g, healed myocardial infarction via left anterior descending coronary artery ligation)^[3]
Dosage:

2.5 mg/kg
Administration:

p.o.; ad libitum; 312 days
Result:

Reduced mortality rate to 53% at day 312, representing a 28% risk reduction versus control.
Reduced 6-month mortality rate to 19%.
Achieved an infarct size of 43%.
Histological analysis showed an external normal boundary of 11.9 mm, internal normal boundary of 7.6 mm, external infarct boundary of 7.4 mm, internal infarct boundary of 6.2 mm, whole area of 60.7 mm², normal area of 52.4 mm², and infarct area of 8.2 mm².

Chemical Information

CAS No. 131741-08-7
Masse moléculaire 280.28
Formule C₁₄H₁₂N₆O
SMILES

N#C/C(C#N)=N/NC1=CC=C(C2=NNC(CC2C)=O)C=C1
Synonyms

(rac)-Levosimendan; (rac)-Simsndan; (rac)-OR-1259
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Signal Pathway Related

Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Lilleberg J, et al. Pharmacokinetics and pharmacodynamics of simendan, a novel calcium sensitizer, in healthy volunteers. Clinical pharmacology and therapeutics. 1994 Nov;56(5):554-63.

[2]. Lilleberg JM, et al. Hemodynamic effects of the novel cardiotonic drug simendan: echocardiographic assessment in healthy volunteers. Cardiovascular drugs and therapy. 1994 Apr;8(2):263-9.

[3]. Levijoki J, et al. Improved survival with simendan after experimental myocardial infarction in rats. European journal of pharmacology. 2001 May 11;419(2-3):243-8.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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