SMD-3040 formate
Based on 1 Customer Validation
SMD-3040 formate is a potent and selective SMARCA2 PROTAC degrader (DC50: 12 nM; Dmax: 91%). SMD-3040 formate can inhibit tumor cell proliferation and exhibits antitumor activity. SMD-3040 formate can be used in the study of tumors such as melanoma.
(Pink: SMARCA2 Target protein ligand; Blue: VHL ligand (HY-112078); Black: linker).
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- Pureté: 99.78%
- Formule: C53H68N10O7S
- Masse moléculaire:989.23
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
SMD-3040 (0-1 μM; 1-48 h) formate can effectively degrade SMARCA2 in cells such as Hela, SK-Mel-5 and SK-Mel-28[1].
SMD-3040 (7 days) formate significantly inhibits cell growth in SMARCA4-deficient cancer cell lines (such as SK-Mel-5, H838, A549, etc.) with GI50 of 8.8-119 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SK-Mel-5 and SK-Mel-28 cellsc
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Concentration:0.01, 0.03, 0.1, 0.3, 1, 3, 10, 30, 100, 300 and 1000 nM
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Incubation Time:24 h
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Result:Inhibited the level of SMARCA2.
Had DC50 values of 20 and 35 nM in K-Mel-5 and SK-Mel-28 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Xenograft mouse models treated SK-Mel-5 melanoma cell line carrying SMARCA4 gene deletion[1]
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Dosage:25 and 50 mg/kg
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Administration:Intravenous injection; twice weekly; two weeks
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Result:Effectively inhibited tumor growth in two different smarca4-deficient xenograft models.
Was well-tolerated in mice.
Chemical Information
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Appearance Solid
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Masse moléculaire 989.23
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Formule C53H68N10O7S
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Color White to off-white
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SMILES
O=C(N[C@H](C(N1[C@H](C(N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C)=O)C[C@@H](O)C1)=O)C(C)(C)C)[C@H]4CC[C@H](CN5CC6(CCC(N7N=CC(C8=C(N)N=NC(C9=C(O)C=CC=C9)=C8)=C7)CC6)C5)CC4.O=CO
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : ≥ 100 mg/mL (101.09 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0109 mL | 5.0544 mL | 10.1089 mL | 25.2722 mL |
| 5 mM | 0.2022 mL | 1.0109 mL | 2.0218 mL | 5.0544 mL | |
| 10 mM | 0.1011 mL | 0.5054 mL | 1.0109 mL | 2.5272 mL | |
| 15 mM | 0.0674 mL | 0.3370 mL | 0.6739 mL | 1.6848 mL | |
| 20 mM | 0.0505 mL | 0.2527 mL | 0.5054 mL | 1.2636 mL | |
| 25 mM | 0.0404 mL | 0.2022 mL | 0.4044 mL | 1.0109 mL | |
| 30 mM | 0.0337 mL | 0.1685 mL | 0.3370 mL | 0.8424 mL | |
| 40 mM | 0.0253 mL | 0.1264 mL | 0.2527 mL | 0.6318 mL | |
| 50 mM | 0.0202 mL | 0.1011 mL | 0.2022 mL | 0.5054 mL | |
| 60 mM | 0.0168 mL | 0.0842 mL | 0.1685 mL | 0.4212 mL | |
| 80 mM | 0.0126 mL | 0.0632 mL | 0.1264 mL | 0.3159 mL | |
| 100 mM | 0.0101 mL | 0.0505 mL | 0.1011 mL | 0.2527 mL |
SMD-3040 formate Related Classifications
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