SR10098
Based on 1 Customer Validation
SR10098 is a benzimidazole-based Nurr1 activator with an EC50 of 24 nM against full-length Nurr1. SR10098 does not directly bind to the ligand-binding domain of Nurr1, regulates transcription via a Nurr1-independent pathway, and exhibits no significant cytotoxicity. SR10098 can be used in studies of Nurr1-related diseases, such as Alzheimer's disease and Parkinson's disease.
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- Pureté : ≥95.0%
- CAS No.: 850705-30-5
- Formule: C14H9FN2O2
- Masse moléculaire:256.24
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Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
Nurr1/NR4A2 24 nM (EC50) |
In Vitro
SR10098 (compound 1) weakly upregulates Nurr1-mediated transcription in HEK293T, PC12 and SK-N-BE (2)-C cells; it activates general transcription via a Nurr1-independent mechanism[1].
SR10098 (400 μM) does not directly bind to the ligand-binding domain of Nurr1, as determined by protein NMR structural footprinting[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 850705-30-5
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Appearance Solid
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Masse moléculaire 256.24
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Formule C14H9FN2O2
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Color White to off-white
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SMILES
O=C(O)C1=CC=C2N=C(NC2=C1)C=3C=CC(F)=CC3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Pureté et documentation
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Fiche technique (266 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SR10098 Related Classifications
HY-W193645 Related Classifications
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