STAT3-IN-9
STAT3-IN-9 is a potent STAT3 inhibitor. STAT3-IN-9 inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). STAT3-IN-9 induces apoptosis and cell cycle arrest at the G2/M phase.
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- CAS No.: 2987726-27-0
- Formule: C22H21N3O4
- Masse moléculaire:391.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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STAT3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
5.73 μM
Compound: C6
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Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay
Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay
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[PMID: 33126089] |
| HCT-116 | IC50 |
>25 μM
Compound: C6
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Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay
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[PMID: 33126089] |
| HepG2 | IC50 |
1.63 μM
Compound: C6
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Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay
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[PMID: 33126089] |
| MDA-MB-231 | IC50 |
5.8 μM
Compound: C6
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Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay
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[PMID: 33126089] |
| MDA-MB-468 | IC50 |
0.16 μM
Compound: C6
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Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay
Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay
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[PMID: 33126089] |
| U-251 | IC50 |
>25 μM
Compound: C6
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Antiproliferative activity against human U-251 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay
Antiproliferative activity against human U-251 cells assessed as reduction in cell growth measured after 48 hrs by CCK8 assay
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[PMID: 33126089] |
STAT3-IN-9 (compound C6) (48 h) shows potent in vitro anti-tumor activity with IC50s of 0.16, 5.80, 1.63, 5.73, >25, >25 µM for MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells, respectively[1].
STAT3-IN-9 (0, 0.2, 1.0, 5.0 µM; 24 h) inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701)[1].
STAT3-IN-9 (0, 0.2, 1 µM; 24 h) induces apoptosis through the mitochondrial Caspase dependent apoptotic pathway[1].
STAT3-IN-9 (0, 0.2, 1 µM; 24 h) induces cell cycle arrest at the G2/M phase in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells
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Concentration:
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Incubation Time:48 h
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Result:Showed potent in vitro anti-tumor activity with IC50s of 0.16, 5.80, 1.63, 5.73, >25, >25 µM for MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells, respectively.
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Cell Line:MDA-MB-468 cells
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Concentration:0, 0.2, 1.0, 5.0 µM
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Incubation Time:24 h
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Result:Inhibited the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701).
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Cell Line:MDA-MB-468 cells
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Concentration:0, 0.2, 1 µM
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Incubation Time:24 h
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Result:Induced apoptosis through the mitochondrial Caspase dependent apoptotic pathway.
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Cell Line:MDA-MB-468 cells
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Concentration:0, 0.2, 1 µM
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Incubation Time:24 h
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Result:Cells were arrest at the G2/M phase in a dose-dependent manner.
Chemical Information
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CAS No. 2987726-27-0
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Masse moléculaire 391.42
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Formule C22H21N3O4
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SMILES
COC1=CC(NC2=CC(C3=CC=NN3C)=CC4=C2OC(C(C)=O)=C4)=CC(OC)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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