Cat. No.: HY-117469

Triptohypol C

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Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an K_d value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1.

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Pureté: 96.56%
CAS No.: 193957-88-9
Formule: C₂₉H₄₀O₄
Masse moléculaire:452.63

Stockage:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Triptohypol C Chemical Structure

CAS No.: 193957-88-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

Nur77/NR4A1

Voir tous les produits spécifiques à Isoform Nuclear Hormone Receptor 4A/NR4A :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.15 μM Compound: 2	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 28688281]
A549	IC₅₀	3.15 μM Compound: 2	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 28865279]
MIA PaCa-2	IC₅₀	0.72 μM Compound: 2	Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay	[PMID: 28688281]
MIA PaCa-2	IC₅₀	0.72 μM Compound: 2	Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay	[PMID: 28865279]

In Vitro

Triptohypol C (compound 3a) (2 μM; 1 h) strongly antagonize the effect of TNFα on inducing IκBα degradation, and inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1^[1].
Triptohypol C (2 μM; 10 h) cause 3.12% apoptosis in HepG2 cells, which is less toxic than Tripterin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Lysates from HepG2 cells (incubated with 20 ng/mL TNFα for 30 min)
Concentration:

2 μM
Incubation Time:

1 h
Result:

Strongly antagonized the effect of TNFα on inducing IκBα degradation

Immunofluorescence^[1]

Cell Line:

HepG2 cells (transfected with Myc-Nur77 and Flag-TRAF2 or Flag-p62)
Concentration:

2 μM
Incubation Time:

1 h
Result:

Promoted the interactions between Nur77 and TRAF2 and p62/SQSTM1.

Apoptosis Analysis^[1]

Cell Line:

HepG2 cells
Concentration:

2 μM
Incubation Time:

10 h
Result:

Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).

In Vivo

Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Zebrafish^[1]
Dosage:

0.5 μM, 1 μM and 1.25 μM
Administration:

72 h
Result:

Had less effect than Tripterin on the death rate and malformation of zebrafish either at a concentration of 1.25 μM for 24 h or at a concentration of 0.5 μM for 72 h.

Chemical Information

CAS No. 193957-88-9
Appearance Solid
Masse moléculaire 452.63
Formule C₂₉H₄₀O₄
Color Light yellow to yellow
SMILES

CC1=C(O)C(O)=CC2=C1CC=C3[C@@]2(C)CC[C@]4(C)[C@]3(C)CC[C@]5(C)[C@@]4([H])C[C@](C)(C(O)=O)CC5
Structure Classification
- Terpenoids
- Triterpenes
- Ketones, Aldehydes, Acids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvant et solubilité

In Vitro:

DMSO : 16.67 mg/mL (36.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2093 mL

11.0465 mL

22.0931 mL

5 mM

0.4419 mL

2.2093 mL

4.4186 mL

10 mM

0.2209 mL

1.1047 mL

2.2093 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chen Z, et al. SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem. 2019 Sep 1;177:171-187. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2093 mL	11.0466 mL	22.0931 mL	55.2328 mL
	5 mM	0.4419 mL	2.2093 mL	4.4186 mL	11.0466 mL
	10 mM	0.2209 mL	1.1047 mL	2.2093 mL	5.5233 mL
	15 mM	0.1473 mL	0.7364 mL	1.4729 mL	3.6822 mL
	20 mM	0.1105 mL	0.5523 mL	1.1047 mL	2.7616 mL
	25 mM	0.0884 mL	0.4419 mL	0.8837 mL	2.2093 mL
	30 mM	0.0736 mL	0.3682 mL	0.7364 mL	1.8411 mL

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Triptohypol C

Immunology/Inflammation Compound Library

Natural Product Library

Autophagy Compound Library

Terpenoids Library

Plant-Sourced Natural Product Library

Nuclear Receptor Compound Library

Mitophagy Compound Library

Bioactive Compound Library Max

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Voir tous les produits spécifiques à Isoform Nuclear Hormone Receptor 4A/NR4A

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Triptohypol C

Immunology/Inflammation Compound Library

Natural Product Library

Autophagy Compound Library

Terpenoids Library

Plant-Sourced Natural Product Library

Nuclear Receptor Compound Library

Mitophagy Compound Library

Bioactive Compound Library Max

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Voir tous les produits spécifiques à Isoform Nuclear Hormone Receptor 4A/NR4A

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Triptohypol C Related Classifications

HY-117469 Related Classifications