TRPM4-IN-4
TRPM4-IN-4 (Compound 118) is a selective TRPM4 inhibitor with an IC50 value of 0.339 μM against hTRPM4. TRPM4-IN-4 inhibits hTRPM4 and mTRPM4. TRPM4-IN-4 can be used for the research of colorectal cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C18H14ClNO5
- Masse moléculaire:359.76
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
TRPM4 0.339 μM (IC50) |
In Vitro
TRPM4-IN-4 (5-10 μM) potently inhibits hTRPM4 in HEK293 cells overexpressing hTRPM4, with an IC50 of 0.339 μM[1].
TRPM4-IN-4 potently blocks endogenous TRPM4 currents in HCT116 cells, with an IC50 of 0.146 μM[1].
TRPM4-IN-4 (5-10 μM) exhibits no inhibitory activity against hTRPM5 in HEK293 cells overexpressing hTRPM5[1].
TRPM4-IN-4 (5-10 μM) effectively inhibits mTRPM4 in tsA201 cells overexpressing mTRPM4 at concentrations up to 10 μM, with better activity than NBA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 359.76
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Formule C18H14ClNO5
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SMILES
O=C(O)C1=CC=C(Cl)C=C1NC(COC2=CC=CC(OCC#C)=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TRPM4-IN-4 Related Classifications
HY-183268 Related Classifications
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