Wrightiadione
Wrightiadione is a selective natural tetracyclic isoflavone kinase inhibitor with inhibitory activity against TrkA and PLK3. The IC50 values of Wrightiadione against TrkA and PLK3 are 55.8 μM and 9.0 μM, respectively. Wrightiadione is found in the dried bark of Wrightia tomentosa. Wrightiadione can be used in studies of leukemia, kinase inhibition and cancer-related signaling pathways.
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- CAS No.: 148180-61-4
- Formule: C16H8O3
- Masse moléculaire:248.24
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
TrkA 55.8 μM (IC50) |
PLK3 9 μM (IC50) |
In Vitro
Wrightiadione (compound 1) at 10 μM selectively inhibits TrkA and PLK3 against a kinome panel consisting of 97 cancer-related kinases in a high-throughput binding assay[1].
Wrightiadione inhibits the activity of purified TrkA kinase in radiokinase assays, with an IC50 value of 55.8 μM[1].
Wrightiadione inhibits the kinase activity of purified PLK3 in radiometric kinase assays, with an IC50 of 9.0 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 148180-61-4
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Masse moléculaire 248.24
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Formule C16H8O3
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SMILES
O=C1C=2OC=3C=CC=CC3C(=O)C2C=4C=CC=CC14
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Wrightiadione Related Classifications
HY-N15384 Related Classifications
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