Zelavespib formic
Based on 13 publication(s) in Google Scholar
Zelavespib formic (PU-H71 formic) is a potent Hsp90 inhibitor with an IC50 value of 51 nM for Hsp90 in MDA-MB-468 cells.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 97.39%
- Formule: C19H23IN6O4S
- Masse moléculaire:558.39
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Zelavespib formic
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Nat Commun. 2017 Sep 4;8(1):422. [Abstract]
- Theranostics. 2019 Aug 12;9(20):5769-5783. [Abstract]
- Theranostics. 2019 Jan 1;9(2):554-572. [Abstract]
- J Control Release. 2026 May 10:393:114828. [Abstract]
- Pharmacol Res. 2020 Jan:151:104512. [Abstract]
- Int J Biol Macromol. 2025 Dec 3;337(Pt 1):149421. [Abstract]
- Br J Pharmacol. 2021 Nov;178(22):4485-4500. [Abstract]
- Curr Issues Mol Biol. 2024 Mar 29;46(4):2946-2960. [Abstract]
- Curr Issues Mol Biol. 2023 Aug 23;45(9):7011-7026. [Abstract]
- Viruses. 2021 Apr 2;13(4):610. [Abstract]
- Authorea. April 10, 2021.
- bioRxiv. 2021 Jan 27.
Customer Validation & Images
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WB
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RT-PCR
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Cell Proliferation/Viability Assay
Activité biologique
Description
IC50 & Target
[1]|
HSP90 51 nM (IC50) |
Chemical Information
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Appearance Solid
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Masse moléculaire 558.39
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Formule C19H23IN6O4S
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Color White to off-white
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SMILES
CC(C)NCCCN1C(SC2=C(C=C3OCOC3=C2)I)=NC4=C(N=CN=C14)N.OC=O
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Synonyms
PU-H71 formic
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (13)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286
Zelavespib formic purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
Inoculation of THP-1 cells into 12-well cell culture plates and treated with indicated doses of Pimitespib, IPI-504, PU-H71 (0, 15, 30, 62.5, 125, 250, 500, 1000 nM), or STA-9090 for 18 h. SAMHD1 protein levels were analyzed by western blot.
Zelavespib formic purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
RT-qPCR analysis of SAMHD1 mRNA levels in THP-1 cells treated with indicated concentrations of HSP90 inhibitors (IPI-504 (125, 250, 500 nM), PU-H71, or STA-9090) for 18 h.
Zelavespib formic purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
MTT assay measuring THP-1 cell viability after 18-hour treatment with PU-H71 (0, 125, 250, 500 nM).
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Nat Commun
2017 Sep 4;8(1):422. PMID: 28871086 -
Theranostics
Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System. [Abstract]2019 Aug 12;9(20):5769-5783. PMID: 31534518 -
Theranostics
2019 Jan 1;9(2):554-572. PMID: 30809293 -
J Control Release
The HSP90-dependent bioorthogonal PROTAC prodrug system enables tumor-selective and enhanced protein degradation. [Abstract]2026 May 10:393:114828. PMID: 41839264 -
Pharmacol Res
Destabilization of ROR1 enhances activity of Ibrutinib against chronic lymphocytic leukemia in vivo. [Abstract]2020 Jan:151:104512. PMID: 31726100 -
Int J Biol Macromol
17-AAG promotes the degradation of HSP90 client METTL3 to suppress MYC RNA m6A modification and expression in colorectal cancer. [Abstract]2025 Dec 3;337(Pt 1):149421. PMID: 41349747 -
Br J Pharmacol
Inhibition of heat shock protein (HSP) 90 reverses signal transducer and activator of transcription (STAT) 3-mediated muscle wasting in cancer cachexia mice. [Abstract]2021 Nov;178(22):4485-4500. PMID: 34265073 -
Curr Issues Mol Biol
FLT3 and IRAK4 Inhibitor Emavusertib in Combination with BH3-Mimetics in the Treatment of Acute Myeloid Leukemia. [Abstract]2024 Mar 29;46(4):2946-2960. PMID: 38666914 -
Curr Issues Mol Biol
HSP90 Inhibitor PU-H71 in Combination with BH3-Mimetics in the Treatment of Acute Myeloid Leukemia. [Abstract]2023 Aug 23;45(9):7011-7026. PMID: 37754227 -
Viruses
Deep Transfer Learning Approach for Automatic Recognition of Drug Toxicity and Inhibition of SARS-CoV-2. [Abstract]2021 Apr 2;13(4):610. PMID: 33918368 -
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Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (179.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.48 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.48 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.7909 mL | 8.9543 mL | 17.9086 mL | 44.7716 mL |
| 5 mM | 0.3582 mL | 1.7909 mL | 3.5817 mL | 8.9543 mL | |
| 10 mM | 0.1791 mL | 0.8954 mL | 1.7909 mL | 4.4772 mL | |
| 15 mM | 0.1194 mL | 0.5970 mL | 1.1939 mL | 2.9848 mL | |
| 20 mM | 0.0895 mL | 0.4477 mL | 0.8954 mL | 2.2386 mL | |
| 25 mM | 0.0716 mL | 0.3582 mL | 0.7163 mL | 1.7909 mL | |
| 30 mM | 0.0597 mL | 0.2985 mL | 0.5970 mL | 1.4924 mL | |
| 40 mM | 0.0448 mL | 0.2239 mL | 0.4477 mL | 1.1193 mL | |
| 50 mM | 0.0358 mL | 0.1791 mL | 0.3582 mL | 0.8954 mL | |
| 60 mM | 0.0298 mL | 0.1492 mL | 0.2985 mL | 0.7462 mL | |
| 80 mM | 0.0224 mL | 0.1119 mL | 0.2239 mL | 0.5596 mL | |
| 100 mM | 0.0179 mL | 0.0895 mL | 0.1791 mL | 0.4477 mL |
Zelavespib formic Related Classifications
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