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Cat. No.: HY-101373

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Zolantidine

(Synonyms: SK&F 95282)

Zolantidine (SKF 95282) is a potent, selective and cross the blood-brain barrier histamine H2 antagonist. Zolantidine induces antinociception.

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CAS No.: 104076-38-2
Formule: C₂₂H₂₇N₃OS
Masse moléculaire:381.53

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Zolantidine Chemical Structure

CAS No.: 104076-38-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Zolantidine (SKF 95282) is a potent, selective and cross the blood-brain barrier histamine H2 antagonist. Zolantidine induces antinociception^[1]^[2].

IC₅₀ & Target^[1]

H₂ Receptor

Voir tous les produits spécifiques à Isoform Histamine Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	76 μM Compound: Zolantidine	Cytotoxicity activity against human HepG2 cells after 24 hrs Cytotoxicity activity against human HepG2 cells after 24 hrs	[PMID: 20547797]

In Vivo

Zolantidine (5, 10, 20, 40 mg/kg; s.c.) induces antinociception in cholestatic rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

200-250 g, male Wistar rats (cholestatic rats)^[2]
Dosage:

5, 10, 20, 40 mg/kg
Administration:

S.c.
Result:

Significantly increased tail-flick latencies and induced antinociception.

Chemical Information

CAS No. 104076-38-2
Masse moléculaire 381.53
Formule C₂₂H₂₇N₃OS
SMILES

C1(NCCCOC2=CC=CC(CN3CCCCC3)=C2)=NC4=CC=CC=C4S1
Synonyms

SK&F 95282
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Calcutt CR, et al. Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist. Br J Pharmacol. 1988 Jan;93(1):69-78. [Content Brief]

[2]. Hasanein P. Two histamine H2 receptor antagonists, zolantidine and cimetidine, modulate nociception in cholestatic rats. J Psychopharmacol. 2011 Feb;25(2):281-8. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références

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Zolantidine

Voir tous les produits spécifiques à Isoform Histamine Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Zolantidine Related Classifications

HY-101373 Related Classifications