127-71-9
Chemical Structure
Sulfabenzamide
Synonym(s): N-Sulfanilylbenzamide
- CAS No.: 127-71-9
- Formula:C13H12N2O3S
- Molecular Weight:276.32
IUPAC Name: N-((4-aminophenyl)sulfonyl)benzamide
InChIKey: PBCZLFBEBARBBI-UHFFFAOYSA-N
SMILES: O=C(NS(=O)(C1=CC=C(N)C=C1)=O)C2=CC=CC=C2
Biological Activity: Sulfabenzamide (N-Sulfanilylbenzamide) is a sulfonamide antibacterial agent. Sulfabenzamide exhibit antibacterial activity against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 8739). Sulfabenzamide can promote autophagic cell autophagy in breast cancer cells through p53/ DRAM pathway. Sulfabenzamide increases caspase-3 activity, deactivates PARP1 and DNA-PK, downregulates AKT1 and AKT2. Sulfabenzamide can be used for the researches of breast cancer and bacterial infections[1][2].
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Sulfabenzamide | 99.68% | Sulfabenzamide (N-Sulfanilylbenzamide) is a sulfonamide antibacterial agent. Sulfabenzamide exhibit antibacterial activity against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 8739). Sulfabenzamide can promote autophagic cell autophagy in breast cancer cells through p53/ DRAM pathway. Sulfabenzamide increases caspase-3 activity, deactivates PARP1 and DNA-PK, downregulates AKT1 and AKT2. Sulfabenzamide can be used for the researches of breast cancer and bacterial infections. | ||||||||||||||||||||
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Sulfabenzamide (Standard) | ≥98% | Sulfabenzamide (N-Sulfanilylbenzamide) (Standard) is the analytical standard of Sulfabenzamide (HY-B0960). This product is intended for research and analytical applications. Sulfabenzamide is a sulfonamide antibacterial agent. Sulfabenzamide exhibit antibacterial activity against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 8739). Sulfabenzamide can promote autophagic cell autophagy in breast cancer cells through p53/ DRAM pathway. Sulfabenzamide increases caspase-3 activity, deactivates PARP1 and DNA-PK, downregulates AKT1 and AKT2. Sulfabenzamide can be used for the researches of breast cancer and bacterial infections. | ||||||||||||||||||||
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Sulfabenzamide-d4 | 99.74% | Sulfabenzamide (N-Sulfanilylbenzamide)-d4 is the deuterium labeled Sulfabenzamide (HY-B0960). Sulfabenzamide is a sulfonamide antibacterial agent. Sulfabenzamide exhibit antibacterial activity against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 8739). Sulfabenzamide can promote autophagic cell autophagy in breast cancer cells through p53/ DRAM pathway. Sulfabenzamide increases caspase-3 activity, deactivates PARP1 and DNA-PK, downregulates AKT1 and AKT2. Sulfabenzamide can be used for the researches of breast cancer and bacterial infections. | ||||||||||||||||||||
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References
- [1]. Mohammadpour R, Safarian S, Farahnak S, et al. Sulfabenzamide promotes autophagic cell death in T-47D breast cancer cells through p53/DRAM pathway[J]. J Cell Mol Biol, 2012, 10(1): 41-54.
- [2]. Rostamizadeh S, et al. Synthesis of sulfamethoxazole and sulfabenzamide metal complexes; evaluation of their antibacterial activity. Eur J Med Chem. 2019;171:364-371. [Content Brief]
