2. Apoptosis
  3. Apoptosis Caspase
  4. Caspase-3/7 activator 2

Caspase-3/7 activator 2 is an effective activator of Caspase-3/7. Caspase-3/7 activator 2 has tumor selectivity, anti-proliferative activity and high Apoptosis-inducing ability.

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Caspase-3/7 activator 2

Caspase-3/7 activator 2 Chemische Struktur

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Caspase-3/7 activator 2 Related Antibodies

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Beschreibung

Caspase-3/7 activator 2 is an effective activator of Caspase-3/7. Caspase-3/7 activator 2 has tumor selectivity, anti-proliferative activity and high Apoptosis-inducing ability[1].

IC50 & Target[1]

Caspase-3

 

Caspase-7

 

In Vitro

Caspase-3/7 activator 2 (Compound 7j) inhibits Wi-38, Caco-2 and HepG-2 cells with IC50 values of 16.764 µM, 0.069 µM, 0.087 µM, respectively[1].
Caspase-3/7 activator 2 (0.06 μM; 72 h) significantly inhibits the expression of apoptosis inhibitor Bcl2 in Caco-2 cells (down-regulates Bcl2 by 0.127 folds). Caspase-3/7 activator 2 insignificant effects the morphology of Caco-2 and HepG-2 cells[1].
Caspase-3/7 activator 2 (0.069 µM; 72 h) has the potential to induces apoptosis of Caco-2 cells (the total apoptotic cell populations is 52.650 %)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Caspase-3/7 activator 2 Related Antibodies

Apoptosis Analysis[1]

Cell Line: Caco-2 cells.
Concentration: 0.069 µM.
Incubation Time: 72 h.
Result: Showed to promote cell apoptosis.
Molekulargewicht

558.62

Formel

C32H34N2O7
SMILES

CCOC(C1=CC=C(C=C1)NC(C2(CCCCC2)OC([C@@H](NC(OC3=CC=CC=C3)=O)CC4=CC=CC=C4)=O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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Caspase-3/7 activator 2 Related Classifications

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  • Verdünnungsrechner

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Caspase-3/7 activator 2ApoptosisCaspaseWi-38Caco-2HepG-2Inhibitorinhibitorinhibit

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