CB2R agonist-7
CB2R agonist-7 is a non-biased cannabinoid subtype 2 receptor agonist. CB2R agonist-7 inhibits cAMP production and recruits β-arrestin-2. CB2R agonist-7 has a Ki of 28.8 nM and a Kd of 111 nM for human CB2R, and an IC50 of 2.60 µM for human FAAH. CB2R agonist-7 reduces reactive oxygen species (ROS) production in activated microglia and modulates cytokine release in monocytes and macrophages by reducing pro-inflammatory cytokines and inducing anti-inflammatory cytokines. CB2R agonist-7 can be used for research on neuroinflammation.
For research use only. We do not sell to patients.
- Formula: C22H30BrNO2
- Molecular Weight:420.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Description
IC50 & Target
[1]|
CB2R 28.8 nM (Ki) |
CB2R 111 nM (Kd) |
Arrestin-3/β-Arrestin 2 |
FAAH 2.60 μM (IC50) |
In Vitro
CB2R agonist-7 (10 min-2 h) inhibits human recombinant FAAH with an IC50 of 2.60 µM[1].
CB2R agonist-7 binds hCB2R with a kinetic KD of 111 nM and a residence time of 8.6 min[1].
CB2R agonist-7 is a unbiased CB2R agonist in HEK293T cells, simultaneously activating cAMP inhibition and β-arrestin-2 recruitment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 420.38
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Formula C22H30BrNO2
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SMILES
O=C(NC1(C[C@H](C2)C3)C[C@@H]2C[C@@H]3C1)C4=CC(Br)=CC=C4OCCCCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CB2R agonist-7 Related Classifications
HY-190857 Related Classifications
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