CF-Carvacrol
CF-Carvacrol is an orally active lipid-lowering agent synthesized by merging the pharmacophores of Carvacrol (HY-N0711) and Clofibric acid (HY-B1415). CF-Carvacrol has a good affinity for PPAR-α. CF-Carvacrol has significant hypolipidemic activity and may exert antioxidant and anti-inflammatory activity by activating the Nrf2/HO-1 signaling pathway to reduce liver injury. CF-Carvacrol can be used for the study of CF-induced liver damage.
For research use only. We do not sell to patients.
- Formula: C20H23ClO3
- Molecular Weight:346.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Hyperlipidemic KM mice induced by Triton WR 1339 (20 g)[1]
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Dosage:46.3, 92.6, 185.2 mg/kg
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Administration:i.g. daily for 7 days
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Result:Demonstrated notable efficacy in reducing lipid levels and showed reductions in TG levels by 37.5 % (185.2 mg/kg), 24.58 % (92.6 mg/kg ), and 19.31 % (46.3 mg/kg).
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Animal Model:KM mice (20 g)[1]
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Dosage:572.3 g/kg
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Administration:i.g. daily for a month
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Result:Increased the liver weight and showed lower hepatic injury compared with clofibrate (CF). Decreased ALT and AKP levels. Elevated the levels of plasma SOD and GSH. Elicited minimal oxidative stress response. Decreased TNF-α and IL-6 levels compared to the CF group. Showed no central venous congestion and extensive infiltration of inflammatory cells. Upregulated the expression of Nrf2 and HO-1 proteins.
Chemical Information
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Molecular Weight 346.85
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Formula C20H23ClO3
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SMILES
CC(C1=CC(OC(C(C)(OC2=CC=C(C=C2)Cl)C)=O)=C(C=C1)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CF-Carvacrol Related Classifications
HY-175005 Related Classifications
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