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Cat. No.: HY-175005

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CF-Carvacrol

CF-Carvacrol is an orally active lipid-lowering agent synthesized by merging the pharmacophores of Carvacrol (HY-N0711) and Clofibric acid (HY-B1415). CF-Carvacrol has a good affinity for PPAR-α. CF-Carvacrol has significant hypolipidemic activity and may exert antioxidant and anti-inflammatory activity by activating the Nrf2/HO-1 signaling pathway to reduce liver injury. CF-Carvacrol can be used for the study of CF-induced liver damage.

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화학식: C₂₀H₂₃ClO₃
분자량:346.85

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

CF-Carvacrol Chemical Structure

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All PPAR Isoforms :

All Interleukin Related Isoforms :

In Vivo

CF-Carvacrol (46.3-185.2 mg/kg (0.1335-0.534 mmol/kg), i.g. daily, 7 days) demonstrates a significant and dose-dependent lipid-lowering effect in hyperlipidemic Kunming (KM) mice^[1].
CF-Carvacrol (572.3 g/kg (1.65 mol/kg), i.g. daily, a month) decreases AST, ALT, and AKP levels in mouse plasma, mitigates oxidative stress and inflammation, and ameliorates liver tissue morphology in KM mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Hyperlipidemic KM mice induced by Triton WR 1339 (20 g)^[1]
Dosage:

46.3, 92.6, 185.2 mg/kg
Administration:

i.g. daily for 7 days
Result:

Demonstrated notable efficacy in reducing lipid levels and showed reductions in TG levels by 37.5 % (185.2 mg/kg), 24.58 % (92.6 mg/kg ), and 19.31 % (46.3 mg/kg).

Animal Model:

KM mice (20 g)^[1]
Dosage:

572.3 g/kg
Administration:

i.g. daily for a month
Result:

Increased the liver weight and showed lower hepatic injury compared with clofibrate (CF).
Decreased ALT and AKP levels.
Elevated the levels of plasma SOD and GSH.
Elicited minimal oxidative stress response.
Decreased TNF-α and IL-6 levels compared to the CF group.
Showed no central venous congestion and extensive infiltration of inflammatory cells.
Upregulated the expression of Nrf2 and HO-1 proteins.

Chemical Information

분자량 346.85
화학식 C₂₀H₂₃ClO₃
SMILES

CC(C1=CC(OC(C(C)(OC2=CC=C(C=C2)Cl)C)=O)=C(C=C1)C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shi X, et al. Optimization of clofibrate by carvacrol results in a new hypolipidemic compound with low hepatic injury. Bioorg Med Chem Lett. 2025 May 1;120:130116./ [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

CF-Carvacrol

All PPAR Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CF-Carvacrol Related Classifications

HY-175005 Related Classifications