2-Hydroxypalmitic acid
Based on 1 publication(s) in Google Scholar
2-Hydroxypalmitic acid is an intermediate in the phytosphingosine metabolic pathway. 2-Hydroxypalmitic acid is exclusively incorporated into sphingolipids and not used for other lipids. 2-Hydroxypalmitic acid promotes the production of odd-carbon phosphatidylcholine species. 2-Hydroxypalmitic acid is applicable to studies of Saccharomyces cerevisiae infection.
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- Reinheit : 99.42%
- CAS. Nr.: 764-67-0
- Formel: C16H32O3
- Molecular Weight:272.42
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 2-Hydroxypalmitic acid
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Biologische Aktivität
Beschreibung
IC50 & Target
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Fungal Metabolite |
In Vitro
2-Hydroxypalmitic acid acts as an intermediate in the phytosphingosine metabolic pathway in Saccharomyces cerevisiae BY4741 cells, promoting the production of odd-numbered phosphatidylcholine species[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 764-67-0
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Appearance Solid
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Molecular Weight 272.42
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Formel C16H32O3
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCC(O)C(O)=O
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Structure Classification
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Initial Source
Schizothrix calcicola
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : ≥ 50 mg/mL (183.54 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protokoll
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6708 mL | 18.3540 mL | 36.7080 mL | 91.7701 mL |
| 5 mM | 0.7342 mL | 3.6708 mL | 7.3416 mL | 18.3540 mL | |
| 10 mM | 0.3671 mL | 1.8354 mL | 3.6708 mL | 9.1770 mL | |
| 15 mM | 0.2447 mL | 1.2236 mL | 2.4472 mL | 6.1180 mL | |
| 20 mM | 0.1835 mL | 0.9177 mL | 1.8354 mL | 4.5885 mL | |
| 25 mM | 0.1468 mL | 0.7342 mL | 1.4683 mL | 3.6708 mL | |
| 30 mM | 0.1224 mL | 0.6118 mL | 1.2236 mL | 3.0590 mL | |
| 40 mM | 0.0918 mL | 0.4589 mL | 0.9177 mL | 2.2943 mL | |
| 50 mM | 0.0734 mL | 0.3671 mL | 0.7342 mL | 1.8354 mL | |
| 60 mM | 0.0612 mL | 0.3059 mL | 0.6118 mL | 1.5295 mL | |
| 80 mM | 0.0459 mL | 0.2294 mL | 0.4589 mL | 1.1471 mL | |
| 100 mM | 0.0367 mL | 0.1835 mL | 0.3671 mL | 0.9177 mL |
2-Hydroxypalmitic acid Related Classifications
HY-N7814 Related Classifications
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Keywords
- 2-Hydroxypalmitic acid
- 764-67-0
- Endogenous Metabolite
- Drug Intermediate
- acyl-CoA synthetases Faa1
- Saccharomyces cerevisiae AOY13 cells
- glycerophospholipids
- Saccharomyces cerevisiae BY4741 cells
- MPO1 gene
- odd-numbered phosphatidylcholine
- phytosphingosine metabolic pathway
- yeast cells
- acyl-CoA synthetases Faa4
- Saccharomyces cerevisiae 4378 cells
- Inhibitor
- inhibitor
- inhibit