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Art. -Nr.: HY-16445A

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CNDAC

CNDAC is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC induces DNA damage and apoptosis.

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CAS. Nr.: 135598-68-4
Formel: C₁₀H₁₂N₄O₄
Molecular Weight:252.23

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

CNDAC Chemical Structure

CAS. Nr.: 135598-68-4

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

CNDAC is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC induces DNA damage and apoptosis^[1]^[2].

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
BC-3	IC₅₀	0.23 μM Compound: 1, CNDAC	Cytotoxicity against Kaposi's sarcoma-associated herpesvirus infected BC3 cells after 120 hrs by MTT assay Cytotoxicity against Kaposi's sarcoma-associated herpesvirus infected BC3 cells after 120 hrs by MTT assay	[PMID: 17402726]
DG-75	IC₅₀	0.21 μM Compound: 1, CNDAC	Cytotoxicity against DG75 cells after 120 hrs by MTT assay Cytotoxicity against DG75 cells after 120 hrs by MTT assay	[PMID: 17402726]
HOS-TE85	IC₅₀	6.8 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of Osteosarcoma MNNG-HOS cell line Inhibitory effect tested in vitro for the growth of Osteosarcoma MNNG-HOS cell line	[PMID: 1895307]
KHOS-321H	IC₅₀	4.5 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of Osteosarcoma KHOS-321H cell line Inhibitory effect tested in vitro for the growth of Osteosarcoma KHOS-321H cell line	[PMID: 1895307]
MKN-1	IC₅₀	2.1 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of Stomach adenocarcinoma MKN-1 cell line Inhibitory effect tested in vitro for the growth of Stomach adenocarcinoma MKN-1 cell line	[PMID: 1895307]
MKN-28	IC₅₀	1.7 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of Stomach adenocarcinoma MKN- 28 cell line Inhibitory effect tested in vitro for the growth of Stomach adenocarcinoma MKN- 28 cell line	[PMID: 1895307]
MKN-7	IC₅₀	1.4 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of Stomach adenocarcinoma MKN-7 cell line Inhibitory effect tested in vitro for the growth of Stomach adenocarcinoma MKN-7 cell line	[PMID: 1895307]
MKN-74	IC₅₀	0.04 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of Stomach adenocarcinoma MKN -24 cell line Inhibitory effect tested in vitro for the growth of Stomach adenocarcinoma MKN -24 cell line	[PMID: 1895307]
NUGC-4	IC₅₀	5.2 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of Stomach adenocarcinoma NUGC-4 cell line Inhibitory effect tested in vitro for the growth of Stomach adenocarcinoma NUGC-4 cell line	[PMID: 1895307]
OST	IC₅₀	6.4 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of Osteosarcoma OST cell line Inhibitory effect tested in vitro for the growth of Osteosarcoma OST cell line	[PMID: 1895307]
PC-13	IC₅₀	>100 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-13 cell line Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-13 cell line	[PMID: 1895307]
PC-3	IC₅₀	5.6 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-3 cell line Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-3 cell line	[PMID: 1895307]
PC-8	IC₅₀	4.6 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-8 cell line Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-8 cell line	[PMID: 1895307]
PC-9	IC₅₀	4.4 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-9 cell line Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-9 cell line	[PMID: 1895307]
QG-56	IC₅₀	40 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of Lung squamous-cell carcinoma QG-56 cell line Inhibitory effect tested in vitro for the growth of Lung squamous-cell carcinoma QG-56 cell line	[PMID: 1895307]
SK-ES1	IC₅₀	2.2 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of Osteosarcoma SK-ES-1 cell line Inhibitory effect tested in vitro for the growth of Osteosarcoma SK-ES-1 cell line	[PMID: 1895307]
ST-KM-1	IC₅₀	2.8 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of Stomach adenocarcinoma ST-KM cell line Inhibitory effect tested in vitro for the growth of Stomach adenocarcinoma ST-KM cell line	[PMID: 1895307]
SW480	IC₅₀	0.27 μg/mL Compound: CNDAC	Inhibitory effect tested in vitro for the growth of colon adenocarcinoma SW-480 cell line Inhibitory effect tested in vitro for the growth of colon adenocarcinoma SW-480 cell line	[PMID: 1895307]

In Vitro

CNDAC has a unique mechanism of action: after incorporation into DNA, it induces single-strand breaks (SSBs) that are converted into double-strand breaks (DSBs) when cells go through a second S phase^[1].
Lack of Rad51D and XRCC3 sensitizes cells to CNDAC (0-1 μM; 24 h)^[1].
CNDAC (0-100 μM; 3 days) inhibits proliferation of HL-60 and THP-1 cells^[2].
CNDAC (0-10 μM; 3-6 days) induces apoptosis in HL-60 and THP-1 cells^[2].
CNDAC (6 μM; 48 h) induces cell cycle arrest in the G2 phase following a delayed S phase in HCT116 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF CHO cells
Concentration:

0-1 μM
Incubation Time:

24 h
Result:

Inhibited cell survival with IC₅₀s of 0.006, 0.32, 0.48 and 0.0053 μM against Rad51D-deficient 51D1, Rad51D-complemented 51D1.3, wild-type AA8 and XRCC3-deficient irs1SF cell lines, respectively.

Cell Proliferation Assay^[2]

Cell Line:

HL-60 and THP-1 cells
Concentration:

0-100 μM
Incubation Time:

3 days
Result:

Inhibited proliferation with IC₅₀s of 1.5832 μM and 0.84 μM against HL-60 and THP-1 cells, respectively.

Apoptosis Analysis^[2]

Cell Line:

HL-60 and THP-1 cells
Concentration:

0, 0.5, 1, 2, 3, 4, 5 and 10 μM
Incubation Time:

3, 4, 5, and 6 days
Result:

Induced apoptosis in both cells.

Cell Cycle Analysis^[3]

Cell Line:

HCT116
Concentration:

6 μM
Incubation Time:

48 h
Result:

36 and 36% of cells were arrested in late-S and G2/M phases, respectively.

In Vivo

CNDAC (20mg/kg; i.p.; daily for 10 days) shows antitumor activity in mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CDF1 mice, P388 tumor model^[4]
Dosage:

20 mg/kg
Administration:

Intraperitoneal injection, daily for 10 days
Result:

Greatly increased the survival time and survival rate.

Chemical Information

CAS. Nr. 135598-68-4
Molecular Weight 252.23
Formel C₁₀H₁₂N₄O₄
SMILES

O=C(N=C(N)C=C1)N1[C@H]2[C@@H](C#N)[C@H](O)[C@@H](CO)O2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Liu XJ, et al. Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. hin J Cancer. 2012 Aug;31(8):373-80. [Content Brief]

[2]. Jagan S, et al. Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine. Adv Hematol. 2012;2012:727683. [Content Brief]

[3]. Serova M, et al. Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells. Br J Cancer. 2007 Sep 3;97(5):628-36. [Content Brief]

[4]. Azuma A, et al. Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum. J Med Chem. 1993 Dec 24;36(26):4183-9. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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CNDAC

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

CNDAC Related Classifications

HY-16445A Related Classifications