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GSK2656157

67 Cited Publications
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Based on 67 publication(s) in Google Scholar

GSK2656157 is a selective and ATP-competitive inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) with an IC50 of 0.9 nM.

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  • Reinheit: 99.66%
  • CAS. Nr.: 1337532-29-2
  • Formel: C23H21FN6O
  • Molecular Weight:416.45
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • GSK2656157 Chemical Structure
    GSK2656157 Chemical Structure
  • Experimental Validation Results for GSK2656157
  • Experimental Validation Results for GSK2656157
  • Experimental Validation Results for GSK2656157
  • Experimental Validation Results for GSK2656157
CAS. Nr.: 1337532-29-2
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  • GSK2656157 Chemical Structure
    GSK2656157 Chemical Structure
    1/16
  • 1/16

    GSK2656157 purchased from MedChemExpress. Usage Cited in: J Steroid Biochem Mol Biol. 2021 Jul:211:105893. [Abstract]

    Customer Validation
     Pretreatment with GSK2656157 (1 μM) alleviated the NEFA-induced increase in protein abundance and mRNA levels of PERK, eIF2α, ATF4, and CHOP vis a vis treatment with 1.2 mM NEFA alone.

  • 1/16

    GSK2656157 purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jul 27;2020:8291413. [Abstract]

    Customer Validation
     GSK2656157 not only inhibits the expression of p-PERK, but also reduces the expression of NRF2 in the nucleus (n-NRF2) and total NRF2 (t-NRF2) proteins.

  • 1/16

    GSK2656157 purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2017 May 11;14(1):104. [Abstract]

    Customer Validation
     GSK2656157 treatment suppresses PERK autophosphorylation and TXNIP expression; STF083010 treatment inhibits IRE1α endonuclease activity and TXNIP expression. Representative Western blot and densitometric quantification of protein band optical densities for p-PERK, p-eIF2α/eIF2α, ATF-5, ChREBP, splicing XBP1 (sXBP1) and TXNIP. TXNIP expression is downregulated by GSK2656157 and STF083010 treatment.

  • 1/16

    GSK2656157 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2017 Apr 18;18(4). pii: E854. [Abstract]

    Customer Validation
     GSK2656157 treatment suppresses TXNIP expression and the number of TUNEL-positive cells. TXNIP expression is significantly suppressed by the GSK2656157 (300 μg) treatment.

  • GSK2656157