Goserelin
Based on 2 publication(s) in Google Scholar
Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer.
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- CAS. Nr.: 65807-02-5
- Formel: C59H84N18O14
- Molecular Weight:1269.41
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Goserelin
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Biologische Aktivität
GnRH[1]
Goserelin (1 nM-1 mM; 48-72 hours) promots EOC cell apoptosis[1].
Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genes in SKOV3-ip cells[1].
Goserelin (100 μM; 24-72 hours) influences EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)
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Concentration:1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1 mM
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Incubation Time:48 hours, 72 hours
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Result:Significantly increased the total apoptosis rate of SKOV3-ip, SKOV3 and A2780 cells.
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Cell Line:SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)
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Concentration:1 nM, 10 nM, 100 nM, 1μM , 10 μM, 100 μM, 1 mM
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Incubation Time:48 hours, 72 hours
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Result:The expression of cleaved-caspase-3 and cleaved-PARP were observably increased at 100 μM.
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Cell Line:SKOV3-ip cells
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Concentration:100 μM
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Incubation Time:24 hours, 48 hours, 72 hours
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Result:Expression of human apoptosis-related genes regulated
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Five-week-old specific-pathogen free (SPF) female nude mice (18-20 g), subcutaneous xenograft tumor model[1]
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Dosage:100 µg/mice
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Administration:Subcutaneous injection, daily, for 19 days
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Result:Significantly increased the proportion of apoptotic cells in the subcutaneous xenograft tumors
Chemical Information
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CAS. Nr. 65807-02-5
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Molecular Weight 1269.41
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Formel C59H84N18O14
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Synonyms
ICI 118630
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Sequence
{Glp}-His-Trp-Ser-Tyr-Ser(OtBu)-Leu-Arg-Pro-{Hydrazinecarboxamide}
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Sequence Shortening
{Glp}-HWSY-Ser(OtBu)-LRP-{Hydrazinecarboxamide}
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Environ Sci Technol
A Novel Screening Framework Integrating a Two-Cell Assay System and Computational Toxicology to Identify Disruptors of the GnRH Neuron-Gonadotrope Axis. [Abstract]2026 Apr 7;60(13):9881-9894. PMID: 41872703 -
Commun Biol
Diurnal testosterone oscillations gate drug delivery via phase separation of ZO-1 at the blood-testis barrier in mice. [Abstract]2026 Jun 1. PMID: 42219451
Reinheit & Dokumentation
Verweise
[1]. Ning Zhang, et al. Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway. Oncol Rep. 2018 Mar; 39(3): 1034–1042. [Content Brief]
[2]. Halle C F Moore, et al. Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy. N Engl J Med. 2015 Mar 5;372(10):923-32. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Goserelin Related Classifications
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