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Art. -Nr.: HY-U00295

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Melarsonyl

Name: Melarsonyl
Brand: MedChemExpress
SKU: HY-U00295
Availability: PreOrder

(Synonyms: Melarsonic acid)

Melarsonyl (Melarsonic acid) is an anthelmintic agent which can inhibit parasite potently.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 37526-80-0
Formel: C₁₃H₁₃AsN₆O₄S₂
Molecular Weight:456.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Melarsonyl Chemical Structure

CAS. Nr.: 37526-80-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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- IC₅₀ & Target
- In Vivo
Chemical Information
Protokoll
Reinheit & Dokumentation
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Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

Melarsonyl (Melarsonic acid) is an anthelmintic agent which can inhibit parasite potently.

IC₅₀ & Target

Parasite^[1]

Alle Parasite Isoform-spezifische Produkte anzeigen :

In Vivo

For acute infections produced by T. brucei brucei GVR, Potassium Melarsonyl exhibits trypanocidal activities. Potassium Melarsonyl (Trimelarsan) cures less than 50% mice at a dose of 25 μmol/kg for 4 consecutive days. At 60 μmol/kg, it cures all the mice in a chronic-infection model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 37526-80-0
Appearance Solid
Molecular Weight 456.33
Formel C₁₃H₁₃AsN₆O₄S₂
Color Light yellow to yellow
SMILES

O=C(C1S[As](C2=CC=C(NC3=NC(N)=NC(N)=N3)C=C2)SC1C(O)=O)O
Synonyms

Melarsonic acid
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

Animal Administration^[1]

Mice^[1]

Mice are infected i.p. with 10⁴ bloodstream trypomastigotes taken from an infected mouse and suspended in 0.1 mL of phosphate-buffered saline, pH 7.2. The infection is allowed to develop for 24 h before treatment is begun. Ten infected mice are used as controls and received only excipient, 1% carboxymethylcellulose by the i.p. route in a 0.1 ml volume. The other mice receive a single dose of the diluted or suspended Potassium Melarsonyl (20, 40, 60 μmol/kg) in the same manner. Six mice are used per dose. The trypanocidal activity is evaluated by the mean survival time of treated mice for each dose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Loiseau PM, et al. Contribution of dithiol ligands to in vitro and in vivo trypanocidal activities of dithiaarsanes and investigation of ligand exchange in an aqueous solution. Antimicrob Agents Chemother. 2000 Nov;44(11):2954-61. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Melarsonyl

Alle Parasite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vivo

Chemical Information

Protokoll

Animal Administration[1]

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Melarsonyl Related Classifications

HY-U00295 Related Classifications

Bioz

Keywords

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IC₅₀ & Target

Animal Administration^[1]