Adenosine-d
Based on 1 Customer Validation
Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
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- Reinheit: 99.97%
- CAS. Nr.: 109923-50-4
- Formel: C10H12DN5O4
- Molecular Weight:268.25
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 109923-50-4
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Unlabeled Cas 58-61-7
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Appearance Solid
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Molecular Weight 268.25
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Formel C10H12DN5O4
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Color White to off-white
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SMILES
NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=N2)=NC([2H])=N1
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Synonyms
Adenine riboside-d1; D-Adenosine-d
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 33.33 mg/mL (124.25 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 2007;14(7):1315-1323. [Content Brief]
[3]. Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98(3):1591-1625. [Content Brief]
[4]. Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009;111(4):904-915. [Content Brief]
[5]. Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 2019;41(2):829-838. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7279 mL | 18.6393 mL | 37.2787 mL | 93.1966 mL |
| 5 mM | 0.7456 mL | 3.7279 mL | 7.4557 mL | 18.6393 mL | |
| 10 mM | 0.3728 mL | 1.8639 mL | 3.7279 mL | 9.3197 mL | |
| 15 mM | 0.2485 mL | 1.2426 mL | 2.4852 mL | 6.2131 mL | |
| 20 mM | 0.1864 mL | 0.9320 mL | 1.8639 mL | 4.6598 mL | |
| 25 mM | 0.1491 mL | 0.7456 mL | 1.4911 mL | 3.7279 mL | |
| 30 mM | 0.1243 mL | 0.6213 mL | 1.2426 mL | 3.1066 mL | |
| 40 mM | 0.0932 mL | 0.4660 mL | 0.9320 mL | 2.3299 mL | |
| 50 mM | 0.0746 mL | 0.3728 mL | 0.7456 mL | 1.8639 mL | |
| 60 mM | 0.0621 mL | 0.3107 mL | 0.6213 mL | 1.5533 mL | |
| 80 mM | 0.0466 mL | 0.2330 mL | 0.4660 mL | 1.1650 mL | |
| 100 mM | 0.0373 mL | 0.1864 mL | 0.3728 mL | 0.9320 mL |
Adenosine-d Related Classifications
HY-B0228S Related Classifications
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