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Art. -Nr.: HY-129188

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CCT369260

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CCT369260 (compound 1), a chemical probe, is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC₅₀ of 520 nM.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.67%
CAS. Nr.: 2647503-57-7
Formel: C₂₄H₃₁ClF₂N₆O₂
Molecular Weight:508.99

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

CCT369260 Chemical Structure

CAS. Nr.: 2647503-57-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

CCT369260 (compound 1), a chemical probe, is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC₅₀ of 520 nM^[1].

IC₅₀ & Target

IC50: 520 nM (BCL6)^[1].

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
OCI-Ly1	DC₅₀	0.049 μM Compound: 1; CCT369260	Induction of BCL6 degradation in human OCI-LY1 cells incubated for 2 hrs by MSD electrochemiluminescent immunoassay Induction of BCL6 degradation in human OCI-LY1 cells incubated for 2 hrs by MSD electrochemiluminescent immunoassay	[PMID: 32275432]
OCI-Ly1	GI₅₀	0.035 μM Compound: 1; CCT369260	Antiproliferative activity agianst human OCI-LY1 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay Antiproliferative activity agianst human OCI-LY1 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay	[PMID: 32275432]
OCI-Ly3	GI₅₀	1.6 μM Compound: 1; CCT369260	Antiproliferative activity agianst human OCI-LY3 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay Antiproliferative activity agianst human OCI-LY3 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay	[PMID: 32275432]
SUD4	GI₅₀	0.092 μM Compound: 1; CCT369260	Antiproliferative activity agianst human SUDHL4 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay Antiproliferative activity agianst human SUDHL4 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay	[PMID: 32275432]

In Vivo

CCT369260 (compound 1, 15 mg/kg, po, single dose) significantly inhibits BCL6 in OCI-Ly1 DLBCL xenograft model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

OCI-Ly1 DLBCL xenograft model (female SCID mice)^[1].
Dosage:

15 mg/kg.
Administration:

PO, single dose.
Result:

Decreased the levels of BCL6 in the tumor observed up to 10 h after administration.

Animal Model:

Female Balb/C mice^[1].
Dosage:

1 mg/kg iv and 5 mg/kg po (Pharmacokinetic Analysis).
Administration:

IV and PO
Result:

Demonstrated moderate clearance (CL 20 mL min⁻¹ kg⁻¹) with mean oral bioavailability of 54%.

Chemical Information

CAS. Nr. 2647503-57-7
Appearance Solid
Molecular Weight 508.99
Formel C₂₄H₃₁ClF₂N₆O₂
Color White to off-white
SMILES

O=C1N(CCC(C)(O)C)C2=CC(NC3=NC(N4C[C@@H](C)C(F)(F)[C@@H](C)C4)=NC=C3Cl)=CC=C2N1C
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 300 mg/mL (589.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9647 mL

9.8234 mL

19.6468 mL

5 mM

0.3929 mL

1.9647 mL

3.9294 mL

10 mM

0.1965 mL

0.9823 mL

1.9647 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Benjamin R Bellenie, et al. Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders. J Med Chem. 2020 Apr 23;63(8):4047-4068. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9647 mL	9.8234 mL	19.6468 mL	49.1169 mL
	5 mM	0.3929 mL	1.9647 mL	3.9294 mL	9.8234 mL
	10 mM	0.1965 mL	0.9823 mL	1.9647 mL	4.9117 mL
	15 mM	0.1310 mL	0.6549 mL	1.3098 mL	3.2745 mL
	20 mM	0.0982 mL	0.4912 mL	0.9823 mL	2.4558 mL
	25 mM	0.0786 mL	0.3929 mL	0.7859 mL	1.9647 mL
	30 mM	0.0655 mL	0.3274 mL	0.6549 mL	1.6372 mL
	40 mM	0.0491 mL	0.2456 mL	0.4912 mL	1.2279 mL
	50 mM	0.0393 mL	0.1965 mL	0.3929 mL	0.9823 mL
	60 mM	0.0327 mL	0.1637 mL	0.3274 mL	0.8186 mL
	80 mM	0.0246 mL	0.1228 mL	0.2456 mL	0.6140 mL
	100 mM	0.0196 mL	0.0982 mL	0.1965 mL	0.4912 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

Produktname:
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CCT369260

Apoptosis Compound Library

Anti-Cancer Compound Library

Orally Active Compound Library

Anti-Blood Cancer Compound Library

Mitochondria-Targeted Compound Library

Transcription Factor-Targeted Library

Molecular Glue Compound Library

Heterocyclic Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Mitophagy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

CCT369260

Apoptosis Compound Library

Anti-Cancer Compound Library

Orally Active Compound Library

Anti-Blood Cancer Compound Library

Mitochondria-Targeted Compound Library

Transcription Factor-Targeted Library

Molecular Glue Compound Library

Heterocyclic Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Mitophagy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

CCT369260 Related Classifications

HY-129188 Related Classifications