BM-531
BM-531 is a dual-acting agent for thromboxane receptor (TXA2) antagonism and thromboxane synthase inhibition. BM-531 exerts anti-aggregatory effects on human citrated platelet-rich plasma (PRP), inhibiting Arachidonic acid (HY-109590A)-induced aggregation with an ED100 of 0.125 μM and U-46619 (HY-108566)-induced aggregation with an ED50 of 0.482 μM. BM-531 inhibits high-K+-induced contraction of porcine uterine smooth muscle.
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- CAS. Nr.: 284464-46-6
- Formel: C17H26N4O5S
- Molecular Weight:398.48
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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TXA2 7.8 nM (IC50) |
BM-531 (0.0001-10 μM) shows high affinity for TXA2 receptor on human washed platelets with an IC50 of 0.0078 μM (displacing [3H]SQ-29548)[1].
BM-531 exerts anti-aggregatory effects on human citrated platelet-rich plasma (PRP), inhibiting Arachidonic acid (HY-109590A)-induced aggregation with an ED100 of 0.125 μM and U-46619 (HY-108566)-induced aggregation with an ED50 of 0.482 μM[1].
BM-531 (10 μM, 1 h) inhibits high-K+-induced contraction of porcine uterine smooth muscle[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 284464-46-6
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Molecular Weight 398.48
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Formel C17H26N4O5S
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SMILES
O=S(C1=CC([N+]([O-])=O)=CC=C1NC2CCCCC2)(NC(NC(C)(C)C)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Dogné JM, et al. Effects of a novel non-carboxylic thromboxane A2 receptor antagonist (BM-531) derived from torasemide on platelet function. Prostaglandins Leukot Essent Fatty Acids. 2000 May;62(5):311-7. [Content Brief]
[2]. Cao J, et al. Thromboxane A2 (TP) receptor in the non-pregnant porcine myometrium and its role in regulation of spontaneous contractile activity. Eur J Pharmacol. 2004 Feb 6;485(1-3):317-27. [Content Brief]
[3]. Michaux C, et al. N-tert-butyl-N'-(2-cyclohexylamino-5-nitrobenzenesulfonyl)urea, BM531, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition. Acta Crystallogr C. 2002 Oct;58(Pt 10):o621-3. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BM-531 Related Classifications
HY-135447 Related Classifications
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