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Art. -Nr.: HY-P11646

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Brazzein

Name: Brazzein
Brand: MedChemExpress
SKU: HY-P11646
Availability: PreOrder

Brazzein is a functional sweetener with antioxidant, anti-inflammatory, and anti-allergic activities.

Brazzein inhibits COX-2 with an IC₅₀ of 12.62 μM. Brazzein exhibits strong antioxidant effects, showing ABTS radical scavenging activity (IC₅₀ = 12.55 μM). Brazzein shows no antibacterial or antifungal activity. Brazzein can be used for the research of obesity, metabolic disorder, inflammation.

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CAS. Nr.: 178359-31-4
Formel: C₂₇₆H₄₁₀N₇₆O₈₉S₈
Molecular Weight:6473.18

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Brazzein Chemical Structure

CAS. Nr.: 178359-31-4

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Brazzein is a functional sweetener with antioxidant, anti-inflammatory, and anti-allergic activities.

IC₅₀ & Target^[1]

COX-2

12.62 μM (IC₅₀)

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In Vitro

Brazzein (15-30 μM) shows strong ABTS radical scavenging activity with an IC₅₀ of 12.55 μM in cell-free conditions^[1].
Brazzein (15-30 μM; 30 min) shows weaker DPPH radical scavenging activity compared to ABTS, with an IC₅₀ > 30 μM in cell-free conditions^[1].
Brazzein (3-25 μM) inhibits human COX-2 activity with an IC₅₀ of 12.62 μM in cell-free conditions^[1].
Brazzein (1–15 μM) shows weak anti-inflammatory activity in RAW 264.7 cells, with an IC₅₀ > 15 μM for NO production inhibition^[1].
Brazzein (1-15 μM) has no cytotoxic effect on RAW 264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 178359-31-4
Molecular Weight 6473.18
Formel C₂₇₆H₄₁₀N₇₆O₈₉S₈
Sequence

Glp-Asp-Lys-Cys-Lys-Lys-Val-Tyr-Glu-Asn-Tyr-Pro-Val-Ser-Lys-Cys-Gln-Leu-Ala-Asn-Gln-Cys-Asn-Tyr-Asp-Cys-Lys-Leu-Asp-Lys-His-Ala-Arg-Ser-Gly-Glu-Cys-Phe-Tyr-Asp-Glu-Lys-Arg-Asn-Leu-Gln-Cys-Ile-Cys-Asp-Tyr-Cys-Glu-Tyr (disulfide bridge:Cys4-Cys52,Cys16-Cys37,Cys22-Cys47,Cys26-Cys49)
Sequence Shortening

Glp-DKCKKVYENYPVSKCQLANQCNYDCKLDKHARSGECFYDEKRNLQCICDYCEY (disulfide bridge:Cys4-Cys52,Cys16-Cys37,Cys22-Cys47,Cys26-Cys49)
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chung JH, et al. Antioxidant, anti-inflammatory, and anti-allergic activities of the sweet-tasting protein brazzein. Food Chem. 2018;267:163-169. [Content Brief]

[2]. Martinez Raquel, et al. Brazzein as a sustainable alternative to sugar: production, perception, and public health impact. J Appl Biotechnol Bioeng. 2025;12(1):45-48.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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Brazzein

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