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Art. -Nr.: HY-190595

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C129-0055

C129-0055 is a TRPV1 channel antagonist. C129-0055 can be used in pain research.

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CAS. Nr.: 442897-27-0
Formel: C₂₅H₂₇N₃O
Molecular Weight:385.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

C129-0055 Chemical Structure

CAS. Nr.: 442897-27-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
Chemical Information
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Biologische Aktivität

Beschreibung

C129-0055 is a TRPV1 channel antagonist. C129-0055 can be used in pain research^[1].

IC₅₀ & Target

^[1]

TRPV1

Alle TRP Channel Isoform-spezifische Produkte anzeigen :

In Vitro

C129-0055 (0.005-100 μM; 20 min) inhibits Capsaicin (HY-10448)-induced TRPV1 calcium flux in HEK293-TRPV1 cells, with an FDSS IC₅₀ of 9.74 μM^[1].
C129-0055 (0.12-10 μM) inhibits Capsaicin-induced TRPV1 currents in HEK293-TRPV1 cells in a concentration-dependent manner, with a patch-clamp IC₅₀ of 0.95 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 442897-27-0
Molecular Weight 385.50
Formel C₂₅H₂₇N₃O
SMILES

CC1=CC(N2CCCCC2)=NC3=C1C=C(NC(/C=C/C4=CC=C(C)C=C4)=O)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Guo Y, et al. Discovery and mechanism analysis of novel TRPV1 antagonists driven by multi-dimensional virtual screening and dynamic simulation. European journal of medicinal chemistry. 2026 Sep 10;320:119311.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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C129-0055

Alle TRP Channel Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

C129-0055 Related Classifications

HY-190595 Related Classifications

Bioz

Keywords

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