Art. -Nr.: HY-B1511

Cyclic AMP

(Synonyms: Cyclic adenosine monophosphate; Adenosine cyclic 3', 5'-monophosphate; cAMP)

30 Cited Publications

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Based on 30 publication(s) in Google Scholar

Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes.

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Reinheit: 99.95%
CAS. Nr.: 60-92-4
Formel: C₁₀H₁₂N₅O₆P
Molecular Weight:329.21

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Cyclic AMP Chemical Structure

CAS. Nr.: 60-92-4

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (30)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

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In Vitro

Cyclic AMP (Cyclic adenosine monophosphate) modulates mediator generation. Cyclic AMP suppresses the expression of pro-inflammatory cytokines, including TNF-α and IL-12, and enhances the production of the anti-inflammatory cytokine IL-10.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 60-92-4
Appearance Solid
Molecular Weight 329.21
Formel C₁₀H₁₂N₅O₆P
Color White to off-white
SMILES

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP4(O)=O)[C@@H](CO4)O3
Synonyms

Cyclic adenosine monophosphate; Adenosine cyclic 3', 5'-monophosphate; cAMP
Structure Classification
- Others
Initial Source
- Microorganisms
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (30)

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Journal Impact Factor

Immunity

The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2. [Abstract]

2025 Mar 21:S1074-7613(25)00093-7. PMID: 40139186
Cell Stem Cell

Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems. [Abstract]

2026 May 15:S1934-5909(26)00158-X. PMID: 42143017
Cell Host Microbe

Bacterial entrapment of a fungal carbon repressor prevents plant colonization. [Abstract]

2026 Mar 11;34(3):494-508.e7. PMID: 41747724
Nat Neurosci

Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations. [Abstract]

2022 Jun;25(6):805-817. PMID: 35637371
Nat Protoc

Neural cell isolation from adult macaques for high-throughput analyses and neurosphere cultures. [Abstract]

2023 Jun;18(6):1930-1957. PMID: 37045994
Adv Sci (Weinh)

Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury. [Abstract]

2025 May 14:e2500566. PMID: 40365742
Adv Sci (Weinh)

Sleep Deprivation Triggers the Excessive Activation of Ovarian Primordial Follicles via β2 Adrenergic Receptor Signaling. [Abstract]

2024 Sep 4:e2402393. PMID: 39229959

Cyclic AMP purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]

After treating KGN cells with 20 μM of cAMP for 24 h, the expression level of KITL significantly increased.
Biomaterials

LDH nanoparticles-doped cellulose nanofiber scaffolds with aligned microchannels direct high-efficiency neural regeneration and organized neural circuit remodeling through RhoA/Rock/Myosin II pathway. [Abstract]

2025 Mar:314:122873. PMID: 39369670
Cancer Lett

Targeting inosine metabolism to enhance EGFR-targeted therapy in lung adenocarcinoma. [Abstract]

2025 Sep 29:634:218069. PMID: 41033606
Mater Today Bio

Age-mimicking hydrogel stiffness recapitulates the mechanical niche of the hippocampus to regulate neural stem cell senescence. [Abstract]

2026 Mar 3:37:102985. PMID: 41852885
Dev Cell

A pathological role of O-GlcNAcylation-driven TR11B production and function in lung adenocarcinoma. [Abstract]

2025 Sep 3:S1534-5807(25)00530-1. PMID: 40930100
Anal Chem

Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]

2025 May 13;97(18):9827-9835. PMID: 40302637
Talanta

A simple, rapid and sensitive HILIC LC-MS/MS method for simultaneous determination of 16 purine metabolites in plasma and urine. [Abstract]

2024 Jan 15:267:125171. PMID: 37696233
J Environ Sci

2026 Jun 25.
Cells

Proof-of-Concept for Long-Term Human Endometrial Epithelial Organoids in Modeling Menstrual Cycle Responses. [Abstract]

2024 Nov 2;13(21):1811. PMID: 39513919

Cyclic AMP purchased from MedChemExpress. Usage Cited in: Cells. 2024 Nov 2;13(21):1811. [Abstract]

Cyclic AMP (0.5 mM; 14 days) treatment following estrogen (E2) treatment from day 14 onwards in hEOs was measured by quantitative polymerase chain reaction (qPCR).

Cyclic AMP purchased from MedChemExpress. Usage Cited in: Cells. 2024 Nov 2;13(21):1811. [Abstract]

Cyclic AMP (0.5 mM; 14 days). Representative immunofluorescent images showing ESR1 (ER), PGR (PR), and PAEP expression at day 21 and 28 through 28-day treatment in hEOs were obtained.

Cyclic AMP purchased from MedChemExpress. Usage Cited in: Cells. 2024 Nov 2;13(21):1811. [Abstract]

Cyclic AMP (0.5 mM; 14 days). Violin plot of ELISA for secreted PAEP (left) and SPP1 (right) from culture supernatant with different hormone treatments at day 21 in hEOs was shown.
Chem Biol Interact

Autophagy attenuates the secondary senescence of endometrial stromal cells induced by Bisphenol S. [Abstract]

2026 Jul 25:435:112138. PMID: 42114668
Exp Neurol

Roles of astrocytic Connexin 43 gap junctional deficit in alpha-synucleinopathy and inflammation relevant to Parkinson's. [Abstract]

2026 Jun 26:115897. PMID: 42362037
FEBS J

Dynamic interaction between Escherichia coli enterotoxins and bacteriocins. [Abstract]

2026 Mar 10. PMID: 41804674
Genes Immun

MTA1-mediated transcriptional repression of Cox2 confers resistance against neutrophil infiltration in endometritis. [Abstract]

2026 Mar 10. PMID: 41807815
PLoS Genet

A C. elegans model of copper deficiency: Dietary interventions rescue CTR1/CHCA-1 copper transporter mutant phenotype. [Abstract]

2026 Jan 23;22(1):e1012013. PMID: 41575937
Endocrinology

Berberine ameliorates obesity by inducing GDF15 secretion by brown adipocytes. [Abstract]

2023 Feb 11;164(4):bqad035. PMID: 36825874
Arch Biochem Biophys

TET3 inhibits the decidualization of human endometrial stromal cells by regulating ITGA10 transcription through recruiting HDAC1/2. [Abstract]

2025 Oct:772:110552. PMID: 40675525
J Reprod Immunol

IL-27 promotes decidualization via the STAT3-ESR/PGR regulatory axis. [Abstract]

2022 Jun;151:103623. PMID: 35430461
Fitoterapia

The stem-derived bioactive fraction of Syringa oblata Lindl. Ameliorates insomnia via cAMP signaling-mediated regulation of neurotransmission, oxidative stress, and inflammation: A multi-omics study. [Abstract]

2026 Apr:190:107182. PMID: 41861857
J Assist Reprod Genet

FXYD1 was identified as a hub gene in recurrent miscarriage and involved in decidualization via regulating Na/K-ATPase activity. [Abstract]

2025 Feb;42(2):665-678. PMID: 39730944

Cyclic AMP purchased from MedChemExpress. Usage Cited in: J Assist Reprod Genet. 2025 Feb;42(2):665-678. [Abstract]

Cyclic AMP (0.5 mM; 4 days). The FOXO1 mRNA expression in T-HESCs transfected with either control vector or FXYD1-overexpression plasmids at 0, 2, and 4 days during decidualization was measured.
STAR Protoc

Protocol to identify the signaling network of nucleotide second messengers in Shigella sonnei. [Abstract]

2026 Mar 20;7(1):104353. PMID: 41671092
bioRxiv

Characterization of Lysine Methylation During Neuronal Differentiation of LUHMES cells. [Abstract]

2026 Jan 2:2025.12.31.696910. PMID: 41509464
bioRxiv

2025 Sep 29.
bioRxiv

2024 July 27.
Methods Mol Biol

Characterizing the Neuron-Glial Interactions by the Co-cultures of Human iPSC-Derived Oligodendroglia and Neurons. [Abstract]

2023:2683:103-111. PMID: 37300770

Lösungsmittel & Löslichkeit

In Vitro:

0.1 M NaOH : 50 mg/mL (151.88 mM; ultrasonic and adjust pH to 6 with NaOH)

H₂O : 2 mg/mL (6.08 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0376 mL

15.1879 mL

30.3757 mL

5 mM

0.6075 mL

3.0376 mL

6.0751 mL

10 mM

0.3038 mL

1.5188 mL

3.0376 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. G M Fimia, et al. Cyclic AMP signaling. J Cell Sci. 2001 Jun;114(Pt 11):1971-2. [Content Brief]

[2]. Paolo Sassone-Corsi, et al. The cyclic AMP pathway. Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12):a011148. [Content Brief]

[3]. Aronoff DM, et, al. Short communication: differences between macrophages and dendritic cells in the cyclic AMP-dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis. J Interferon Cytokine Res. 2006 Nov;26(11):827-33. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / 0.1 M NaOH	1 mM	3.0376 mL	15.1879 mL	30.3757 mL	75.9394 mL
H₂O / 0.1 M NaOH	5 mM	0.6075 mL	3.0376 mL	6.0751 mL	15.1879 mL
0.1 M NaOH	10 mM	0.3038 mL	1.5188 mL	3.0376 mL	7.5939 mL
	15 mM	0.2025 mL	1.0125 mL	2.0250 mL	5.0626 mL
	20 mM	0.1519 mL	0.7594 mL	1.5188 mL	3.7970 mL
	25 mM	0.1215 mL	0.6075 mL	1.2150 mL	3.0376 mL
	30 mM	0.1013 mL	0.5063 mL	1.0125 mL	2.5313 mL
	40 mM	0.0759 mL	0.3797 mL	0.7594 mL	1.8985 mL
	50 mM	0.0608 mL	0.3038 mL	0.6075 mL	1.5188 mL
	60 mM	0.0506 mL	0.2531 mL	0.5063 mL	1.2657 mL
	80 mM	0.0380 mL	0.1898 mL	0.3797 mL	0.9492 mL
	100 mM	0.0304 mL	0.1519 mL	0.3038 mL	0.7594 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Cyclic AMP

30 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Cyclic AMP

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (30)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Cyclic AMP Related Classifications

HY-B1511 Related Classifications