Caspofungin diacetate
Based on 12 publication(s) in Google Scholar
Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.
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- Reinheit : 99.74%
- CAS. Nr.: 179463-17-3
- Formel: C56H96N10O19
- Molecular Weight:1213.42
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Speicherung:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Publications Citing Use of MedChemExpress (MCE) Caspofungin diacetate
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Cell Mol Immunol. 2023 Apr;20(4):351-364. [Abstract]
- Adv Sci (Weinh). 2026 Jun 28:e76369. [Abstract]
- J Agric Food Chem. 2025 Jul 9;73(27):16787-16803. [Abstract]
- EMBO Rep. 2022 Jun 7;23(6):e53932. [Abstract]
- Front Microbiol. 2024 Jul 30:15:1450557. [Abstract]
- Bioorg Chem. 2025 Dec:167:109253. [Abstract]
- Sci Rep. 2026 Jun 27.
- J Fungi (Basel). 2024 May 31;10(6):397. [Abstract]
- Microbiol Spectr. 2025 May 6;13(5):e0318524. [Abstract]
- Cell Physiol Biochem. 2016;39(3):939-49. [Abstract]
- Research Square Preprint. 2024 Nov 20.
Customer Validation & Images
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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Histological Imaging/Staining
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Microbiological Assay
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Cell Proliferation/Viability Assay
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Biologische Aktivität
Beschreibung
In Vivo
Caspofungin diacetate (0.41-41 μM; i.p.; for 5 weeks; male C57BL/6 mice) is a safe antifungal agent at vitreal concentrations of 0.41 to 4.1 μM in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Complement component 5-deficient DBA/2N mice[1]
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Dosage:1, 2, 4 and 8 mg/kg
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Administration:Intraperitoneal injection; daily, for 7 days
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Result:Reduced the concentration of Candida load in the brain.
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Animal Model:Male C57BL/6 mice[2]
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Dosage:0.41, 1.2, 2.5, 4.1, and 41 μM
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Administration:Intraperitoneal injection; for 5 weeks
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Result:Had nonsignificant alterations in their ERG waveforms from 0.41 to 4.1 μM.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 179463-17-3
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Appearance Solid
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Molecular Weight 1213.42
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Formel C56H96N10O19
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Color White to off-white
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SMILES
O=C([C@](NC([C@](NC([C@@](C[C@H]1O)([H])N(C1)C2=O)=O)([H])[C@H](O)[C@H](C(C=C3)=CC=C3O)O)=O)([H])[C@H](O)CCN)N(CC[C@@H]4O)[C@]4([H])C(N[C@@H]([C@@H](C[C@@H](C(N[C@@]2([H])[C@H](O)C)=O)NC(CCCCCCCC[C@@H](C)C[C@@H](C)CC)=O)O)NCCN)=O.OC(C)=O.OC(C)=O
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Synonyms
MK-0991 diacetate; L-743872 diacetate
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (12)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Cell Mol Immunol
A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as potential treatments for lethal COVID-19. [Abstract]2023 Apr;20(4):351-364. PMID: 36864189 -
Adv Sci (Weinh)
Calcineurin-Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata. [Abstract]2026 Jun 28:e76369. PMID: 42365577 -
J Agric Food Chem
Transcription Repressor SsGATA2 Regulates Broad-Spectrum Resistance to Fungicides and Pathogenicity in Sclerotinia sclerotiorum. [Abstract]2025 Jul 9;73(27):16787-16803. PMID: 40558024 -
EMBO Rep
2022 Jun 7;23(6):e53932. PMID: 35403787 -
Front Microbiol
Ketoconazole induces reversible antifungal drug tolerance mediated by trisomy of chromosome R in Candida albicans. [Abstract]2024 Jul 30:15:1450557. PMID: 39139375
Caspofungin diacetate purchased from MedChemExpress. Usage Cited in: Front Microbiol. 2024 Jul 30:15:1450557. [Abstract]
Caspofungin (50 μg; 30 ℃; 2 d) showed clear ZOI for wild-type strain SC5314 and two strains bearing ChrR trisomy and tetrasomy.
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Bioorg Chem
Glycolysis-mediated energy metabolism mechanisms: Synergistic antifungal activity of (±)-methylagrimonolide against drug-resistant Candida albicans. [Abstract]2025 Dec:167:109253. PMID: 41242040
Caspofungin diacetate purchased from MedChemExpress. Usage Cited in: Bioorg Chem. 2025 Dec:167:109253. [Abstract]
Caspofungin (5 mg/kg; i.g.; once daily for 8 d) treatment effectively alleviated the atrophy of thymus and spleen in mice.
Caspofungin diacetate purchased from MedChemExpress. Usage Cited in: Bioorg Chem. 2025 Dec:167:109253. [Abstract]
Caspofungin (5 mg/kg; i.g.; once daily for 8 d) treatment enabled C57BL/6 mice infected with C. albicans ATCC14053-FR to maintain their body weight.
Caspofungin diacetate purchased from MedChemExpress. Usage Cited in: Bioorg Chem. 2025 Dec:167:109253. [Abstract]
HE-stained and PASM-stained sections of kidneys and lungs after treatment. Caspofungin (5 mg/kg; i.g.; once daily for 8 d) diminished lesion areas, reduced inflammatory cell infiltration, and significantly improved renal tubular damage and alveolar edema.
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J Fungi (Basel)
In Vitro Activitiy of Rezafungin in Comparison with Anidulafungin and Caspofungin against Invasive Fungal Isolates (2017 to 2022) in China. [Abstract]2024 May 31;10(6):397. PMID: 38921383 -
Microbiol Spectr
Synergistic antifungal activity of minocycline as an effective augmenting agent of fluconazole against drug-resistant Candida tropicalis. [Abstract]2025 May 6;13(5):e0318524. PMID: 40162832 -
Cell Physiol Biochem
2016;39(3):939-49. PMID: 27513568
Caspofungin diacetate purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2016;39(3):939-49. [Abstract]
Arithmetic means±SEM (n=21) of erythrocyte annexin-V-binding following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Caspofungin (30-60 µg/mL).
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Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (82.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (41.21 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.06 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (2.06 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Reinheit & Dokumentation
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Data Sheet (299 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Flattery AM, et, al. Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis. Antimicrob Agents Chemother. 2011 Jul;55(7):3491-7. [Content Brief]
[2]. Mojumder DK, et, al. Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5796-803. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.8241 mL | 4.1206 mL | 8.2412 mL | 20.6029 mL |
| 5 mM | 0.1648 mL | 0.8241 mL | 1.6482 mL | 4.1206 mL | |
| 10 mM | 0.0824 mL | 0.4121 mL | 0.8241 mL | 2.0603 mL | |
| 15 mM | 0.0549 mL | 0.2747 mL | 0.5494 mL | 1.3735 mL | |
| 20 mM | 0.0412 mL | 0.2060 mL | 0.4121 mL | 1.0301 mL | |
| 25 mM | 0.0330 mL | 0.1648 mL | 0.3296 mL | 0.8241 mL | |
| 30 mM | 0.0275 mL | 0.1374 mL | 0.2747 mL | 0.6868 mL | |
| 40 mM | 0.0206 mL | 0.1030 mL | 0.2060 mL | 0.5151 mL | |
| DMSO | 50 mM | 0.0165 mL | 0.0824 mL | 0.1648 mL | 0.4121 mL |
| 60 mM | 0.0137 mL | 0.0687 mL | 0.1374 mL | 0.3434 mL | |
| 80 mM | 0.0103 mL | 0.0515 mL | 0.1030 mL | 0.2575 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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