CP-113818
Based on 2 publication(s) in Google Scholar
CP-113818 is a potent cholesterol acyltransferase (ACAT) inhibitor. CP-113818 can be used for the research of Alzheimer's disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.70%
- CAS. Nr.: 135025-12-6
- Formel: C24H42N2OS3
- Molecular Weight:470.80
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CP-113818
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Biologische Aktivität
CP-113818 inhibits Aβ production in cell-based experiments[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6, hAPP (human amyloid precursor protein) transgenic mice[1]
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Dosage:0, 0.2, 1.6, 3.2, 4.8, and 7.1 mg/kg/day
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Administration:Via implantable slow-release biopolymer pellets, 21 days for nontransgenic mice or 60 days for hAPP mice
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Result:Reduced total cholesterol levels by 29% in the serum, hepatic free cholesterol and cholesteryl-esters were also decreased in a dose-dependent manner by up to 37% and 93%, respectively in the nontransgenic mice.
Effectively reduced cholesteryl-ester levels of hAPP mice in the absence of adrenal toxicity, reduced plaque numbers, and decreased amyloid load in a gender-independent manner in hAPP mice.
Reduced levels of “insoluble” and soluble Aβ1-40 and Aβ1-42 in the brains of hAPP transgenic mice.
Restored normal spatial learning and memory in female hAPP mice in a morris water maze test.
Reduced processing of endogenous APP but not notch or N-cadherin, without directly inhibiting β- and γ-secretase activities or Aβ aggregation in nontransgenic littermates.
Chemical Information
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CAS. Nr. 135025-12-6
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Appearance Solid
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Molecular Weight 470.80
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Formel C24H42N2OS3
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Color White to off-white
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SMILES
CCCCCCCC[C@H](SCCCCCC)C(NC1=C(SC)N=C(C)C=C1SC)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Rep
Nanoparticle-based itaconate treatment recapitulates low-cholesterol/low-fat diet-induced atherosclerotic plaque resolution. [Abstract]2024 Oct 27;43(11):114911. PMID: 39466775 -
Cancer Sci
SCD1 inhibition enhances the effector functions of CD8+ T cells via ACAT1-dependent reduction of esterified cholesterol. [Abstract]2024 Jan;115(1):48-58. PMID: 37879607
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (212.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1240 mL | 10.6202 mL | 21.2404 mL | 53.1011 mL |
| 5 mM | 0.4248 mL | 2.1240 mL | 4.2481 mL | 10.6202 mL | |
| 10 mM | 0.2124 mL | 1.0620 mL | 2.1240 mL | 5.3101 mL | |
| 15 mM | 0.1416 mL | 0.7080 mL | 1.4160 mL | 3.5401 mL | |
| 20 mM | 0.1062 mL | 0.5310 mL | 1.0620 mL | 2.6551 mL | |
| 25 mM | 0.0850 mL | 0.4248 mL | 0.8496 mL | 2.1240 mL | |
| 30 mM | 0.0708 mL | 0.3540 mL | 0.7080 mL | 1.7700 mL | |
| 40 mM | 0.0531 mL | 0.2655 mL | 0.5310 mL | 1.3275 mL | |
| 50 mM | 0.0425 mL | 0.2124 mL | 0.4248 mL | 1.0620 mL | |
| 60 mM | 0.0354 mL | 0.1770 mL | 0.3540 mL | 0.8850 mL | |
| 80 mM | 0.0266 mL | 0.1328 mL | 0.2655 mL | 0.6638 mL | |
| 100 mM | 0.0212 mL | 0.1062 mL | 0.2124 mL | 0.5310 mL |
CP-113818 Related Classifications
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