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Art. -Nr.: HY-121260

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Cryptopine

Cryptopine is a non-narcotic isoquinoline alkaloid. Cryptopine can reduce the activities of glutathione S-transferase (GST) and glutathione reductase (GR), depletes intracellular glutathione levels, stimulates lipid peroxidation, and induces cytotoxicity by disrupting the cellular defense system. Cryptopine binds stably to key targets of liver cancer and also exhibits anthelmintic activity against Dactylogyrus intermedius. Cryptopine can be used in studies related to liver cancer and Dactylogyrus intermedius infection.

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CAS. Nr.: 482-74-6
Formel: C₂₁H₂₃NO₅
Molecular Weight:369.41

Speicherung:

Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Cryptopine Chemical Structure

CAS. Nr.: 482-74-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Anti-cancer

Cryptopine is a bioactive component of Fumaria indica. It targets key genes and pathways associated with human liver cancer. Network analysis shows that it acts on core liver cancer genes MTOR, MAPK3, PIK3R1 and EGFR, and KEGG enrichment analysis identifies its involvement in pathways including PI3K-AKT-mTOR, MAPK, EGF, p53 and NF-κB^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oxidative StressParasitic Infection

Oxidative Stress

Cryptopine (50-200 mg/kg; p.o.; once daily; for 5 consecutive days) dose-dependently stimulates lipid peroxidation in the liver, spleen, kidney and lung of male Wistar rats, and impairs the glutathione-dependent defense system^[2].

Parasitic Infection

Cryptopine (3-8 mg/L; 48 h) exhibits anthelmintic activity in goldfish infected with Dactylogyrus, with an EC₅₀ of 3.31 mg/L^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (male, 125-150 g)^[2]
Dosage:

50 mg/kg; 100 mg/kg; 150 mg/kg; 200 mg/kg
Administration:

p.o.; daily; 5 days
Result:

Increased liver MDA (a lipid peroxidation product).
Reduced the activities of GSH, GST and GR in the liver, causing severe liver damage.

Related Protocols :

Chemical Information

CAS. Nr. 482-74-6
Appearance Liquid
Molecular Weight 369.41
Formel C₂₁H₂₃NO₅
Color White to off-white
SMILES

CN(CC1=C(C=CC2=C1OCO2)C3)CCC4=C(C3=O)C=C(OC)C(OC)=C4
Structure Classification
- Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Batool S, et al. Network Pharmacology and Bioinformatics Approach Reveals the Multi-Target Pharmacological Mechanism of Fumaria indica in the Treatment of Liver Cancer. Pharmaceuticals (Basel). 2022 May 25;15(6):654.
[Content Brief]

[2]. Aneja R, et al. Stimulation of lipid peroxidation and impairment of glutathione-dependent defense system in Wistar rats treated with cryptopine, a rare non-narcotic opium alkaloid. European journal of drug metabolism and pharmacokinetics. 2004;29(1):31-6. [Content Brief]

[3]. Vrancheva RZ, et al. Alkaloid profiles and acetylcholinesterase inhibitory activities of Fumaria species from Bulgaria. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2016;71(1-2):9-14. [Content Brief]

[4]. Wang GX, et al. In vivo anthelmintic activity of five alkaloids from Macleaya microcarpa (Maxim) Fedde against Dactylogyrus intermedius in Carassius auratus. Veterinary parasitology. 2010 Aug 04;171(3-4):305-13. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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