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Art. -Nr.: HY-P99845

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Dazodalibep

Name: Dazodalibep
Brand: MedChemExpress
SKU: HY-P99845
Price: 480.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: MEDI-4920; VIB 4920)

Kundenbewertung

Based on 1 Customer Validation

Dazodalibep (MEDI-4920) is a non-antibody fusion protein that acts as a CD40 ligand (CD40L) antagonist. Dazodalibep is used in the research of rheumatoid arthritis and Sj?gren's syndrome.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.0%
CAS. Nr.: 2245953-10-8
Molecular Weight:87.82 kDa

Speicherung:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

Dazodalibep Chemical Structure

CAS. Nr.: 2245953-10-8

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Preis

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Species Reactivity
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Dazodalibep (MEDI-4920) is a non-antibody fusion protein that acts as a CD40 ligand (CD40L) antagonist. Dazodalibep is used in the research of rheumatoid arthritis and Sj?gren's syndrome^[1]^[2]^[3].

Isotype

Fusion - Alternative to antigen receptors (domain scaffold: TNC-F3, tenascin domain F3) 2 TNC-F3 domains

Species Reactivity

Human

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In Vitro

Innate ImmunityAdaptive Immunity

Innate Immunity

Adaptive Immunity

Dazodalibep blocks the CD40-CD40L costimulatory interaction between T cells and CD40-expressing B cells and antigen-presenting cells^[2].
Dazodalibep blocks costimulatory signal transduction between T cells, B cells, and antigen-presenting cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Collagen-Induced Arthritis

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Gene ID

959 [NCBI]

Accession

P29965

Target

TNFSF5/CD40L/CD154

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Alternative to antigen receptors (domain scaffold: TNC-F3, tenascin domain F3)2 TNC-F3 domains

Anwendung

ELISA, FACS, Functional assay

Chemical Information

CAS. Nr. 2245953-10-8
Appearance Liquid
Molecular Weight 87.82 kDa
Color Colorless to light yellow
SMILES

[Dazodalibep]
Synonyms

MEDI-4920; VIB 4920
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Bustos AH, et al. Citrullinated peptides as drug candidates for rheumatoid arthritis. Frontiers in immunology. 2025;16:1648913.

[2]. Aung T, et al. Bridging the Gap in Sjögren's Disease: A Comprehensive Review of Unmet Needs, Diagnostic Challenges, and Emerging Therapeutic Strategies. Cureus. 2026 Jul;18(7):e113186.

[3]. Palla P, et al. Infections in Sjögren's disease: a clinical concern or not?. Clinical and experimental rheumatology. 2024 Dec;42(12):2531-2541.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- Isotype
- Species Reactivity
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
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MCE Japan Authorized Agent:

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Dazodalibep

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