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Art. -Nr.: HY-183434

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Desoxymansil

Desoxymansil is an anti-schistosomal agent. In mice, rabbits, dogs and monkeys, Desoxymansil undergoes oxidative metabolism via its isopropylaminomethyl side chain to produce a carboxylic acid metabolite, while this metabolic pathway is absent in rats. In rats, Desoxymansil undergoes α-carbon oxidation of the side chain to form an unstable aminomethanol that decomposes; the intermediate product is reduced to an alcohol metabolite, which is excreted in bile in the form of glucuronide. Desoxymansil can be used for the study of schistosomiasis.

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CAS. Nr.: 21738-41-0
Formel: C₁₄H₂₁N₃O₂
Molecular Weight:263.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Desoxymansil Chemical Structure

CAS. Nr.: 21738-41-0

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Beschreibung

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In Vitro

Desoxymansil (2.0 μmol; 30 min) is extensively hydroxylated to oxamniquine by liver microsomes from rat, mouse, and rabbit, with no detectable N-dealkylation of the isopropyl group^[1].
Desoxymansil is converted to carboxylic acid metabolite V by whole liver homogenates from rabbit and mouse, while rat whole liver homogenates do not produce this metabolite^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Desoxymansil (15-30 mg/kg; i.p.; single dose) administered intraperitoneally to healthy male Wistar rats results in biliary excretion of metabolites III and VI, with no detection of metabolite V, and total biliary radioactivity excretion is higher at the 15 mg/kg dose (28.5%) than at the 30 mg/kg dose (14.7%)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (male, 250-300 g)^[1]
Dosage:

15 mg/kg; 30 mg/kg
Administration:

i.p.; single dose
Result:

Excreted 28.5% of the total administered dose in bile as radioactivity, with 9.1% of the dose present as metabolite III and 4.0% as metabolite VI.
Excreted 14.7% of the total administered dose in bile as radioactivity, with 3.5% of the dose present as metabolite III and 2.8% as metabolite VI.
Detected no metabolite V in bile samples.

Chemical Information

CAS. Nr. 21738-41-0
Molecular Weight 263.34
Formel C₁₄H₂₁N₃O₂
SMILES

CC(C)NCC1NC(C=C2[N+]([O-])=O)=C(C=C2C)CC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Woolhouse NM, Kaye B, Parke DV. Species differences in N-dealkylation of oxamniquine. Xenobiotica. 1979;9(5):323-332.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Desoxymansil

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Desoxymansil Related Classifications

HY-183434 Related Classifications